6DLD

Crystal structure of IgLON5/NEGR1 heterodimer

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, C	IgLON family member 5	polymer	303	33543.4	2	UniProt (A6NGN9) Pfam (PF07686) Pfam (PF13927) In PDB	Homo sapiens (Human)
2	B, D	Neuronal growth regulator 1	polymer	304	33396.3	2	UniProt (Q7Z3B1) Pfam (PF07679) Pfam (PF13927) In PDB	Homo sapiens (Human)	IgLON family member 4
3	E	alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		748.7	1	In PDB GlyTouCan (G81315DD)
4	A, B, C, D	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	15	Chemie (NAG)

Sequence modifications

A, C: 31 - 316 (UniProt: A6NGN9)

PDB	External Database	Details
Asp 20	-	expression tag
Tyr 21	-	expression tag
Lys 22	-	expression tag
Asp 23	-	expression tag
Asp 24	-	expression tag
Asp 25	-	expression tag
Asp 26	-	expression tag
Lys 27	-	expression tag
Ala 28	-	expression tag
Ala 29	-	expression tag
Ala 30	-	expression tag
Leu 317	-	expression tag
Glu 318	-	expression tag
Val 319	-	expression tag
Leu 320	-	expression tag
Phe 321	-	expression tag
Gln 322	-	expression tag

B, D: 38 - 324 (UniProt: Q7Z3B1)

PDB	External Database	Details
Asp 27	-	expression tag
Tyr 28	-	expression tag
Lys 29	-	expression tag
Asp 30	-	expression tag
Asp 31	-	expression tag
Asp 32	-	expression tag
Asp 33	-	expression tag
Lys 34	-	expression tag
Ala 35	-	expression tag
Ala 36	-	expression tag
Ala 37	-	expression tag
Leu 325	-	expression tag
Glu 326	-	expression tag
Val 327	-	expression tag
Leu 328	-	expression tag
Phe 329	-	expression tag
Gln 330	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	133879.5
Branched	Number of molecules	1
	Total formula weight	748.7
Non-Polymers*	Number of molecules	15
	Total formula weight	3318.1
All*	Total formula weight	137946.3

*Water molecules are not included.