6DKP
The complex among DMF5(alpha-D26Y, alpha-Y50A,beta-L98W) TCR, human Class I MHC HLA-A2 and MART-1(26-35)(A27L) peptide
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | HLA class I histocompatibility antigen, A-2 alpha chain | polymer | 276 | 31985.4 | 1 | UniProt (P01892) Pfam (PF00129) Pfam (PF07654) UniProt (by SIFTS) (P04439) | Homo sapiens (Human) | MHC class I antigen A*2 |
| 2 | B (B) | Beta-2-microglobulin | polymer | 100 | 11879.4 | 1 | UniProt (P61769) Pfam (PF07654) | Homo sapiens (Human) | |
| 3 | C (C) | Melanoma antigen recognized by T-cells 1 | polymer | 10 | 985.2 | 1 | UniProt (Q16655) | Homo sapiens | MART-1,Antigen LB39-AA,Antigen SK29-AA,Protein Melan-A |
| 4 | D (D) | DMF5 T-cell Receptor Alpha Chain fusion | polymer | 200 | 22094.4 | 1 | UniProt (A0A075B6T6) UniProt (P01848) Pfam (PF07686) Pfam (PF09291) | Homo sapiens (Human) | |
| 5 | E (E) | DMF5 T-cell Receptor Beta Chain fusion | polymer | 243 | 27132.2 | 1 | UniProt (A0A1B0GXE1) UniProt (K7N5M4) Pfam (PF07686) Pfam (PF07654) | Homo sapiens (Human) |
Sequence modifications
A: 1 - 275 (UniProt: P01892)
B: 2 - 100 (UniProt: P61769)
C: 1 - 10 (UniProt: Q16655)
D: 1 - 91 (UniProt: A0A075B6T6)
D: 109 - 199 (UniProt: P01848)
E: 4 - 97 (UniProt: A0A1B0GXE1)
E: 116 - 245 (UniProt: K7N5M4)
| PDB | External Database | Details |
|---|---|---|
| Met 0 | - | initiating methionine |
| PDB | External Database | Details |
|---|---|---|
| Met 1 | - | initiating methionine |
| PDB | External Database | Details |
|---|---|---|
| Leu 2 | Ala 27 | engineered mutation |
| PDB | External Database | Details |
|---|---|---|
| Met 0 | - | initiating methionine |
| Tyr 26 | Asp 48 | engineered mutation |
| Ala 50 | Tyr 72 | engineered mutation |
| Phe 92 | - | linker |
| Gly 93 | - | linker |
| Gly 94 | - | linker |
| Gly 95 | - | linker |
| Lys 96 | - | linker |
| Leu 97 | - | linker |
| Ile 98 | - | linker |
| Phe 99 | - | linker |
| Gly 100 | - | linker |
| Gln 101 | - | linker |
| Gly 102 | - | linker |
| Thr 103 | - | linker |
| Glu 104 | - | linker |
| Leu 105 | - | linker |
| Ser 106 | - | linker |
| Val 107 | - | linker |
| Lys 108 | - | linker |
| PDB | External Database | Details |
|---|---|---|
| Cys 157 | Thr 49 | conflict |
| PDB | External Database | Details |
|---|---|---|
| Met 3 | - | initiating methionine |
| Trp 98 | - | linker |
| Ser 99 | - | linker |
| Phe 100 | - | linker |
| Gly 101 | - | linker |
| Thr 102 | - | linker |
| Glu 103 | - | linker |
| Ala 104 | - | linker |
| Phe 105 | - | linker |
| Phe 106 | - | linker |
| Gly 107 | - | linker |
| Gln 108 | - | linker |
| Gly 109 | - | linker |
| Thr 110 | - | linker |
| Arg 111 | - | linker |
| Leu 112 | - | linker |
| Thr 113 | - | linker |
| Val 114 | - | linker |
| Val 115 | - | linker |
| PDB | External Database | Details |
|---|---|---|
| Asn 119 | Lys 123 | conflict |
| Lys 120 | Asn 124 | conflict |
| Asp 204 | Asn 208 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 5 |
| Total formula weight | 94076.6 | |
| All* | Total formula weight | 94076.6 |
