6D8X

PPAR gamma LBD complexed with the agonist GW1929

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	Peroxisome proliferator-activated receptor gamma	polymer	297	34152.4	1	UniProt (P37231) Pfam (PF00104) In PDB	Homo sapiens (Human)	PPAR-gamma,Nuclear receptor subfamily 1 group C member 3
2	A	(2~{S})-3-[4-[2-[methyl(pyridin-2-yl)amino]ethoxy]phenyl]-2-[[2-(phenylcarbonyl)phenyl]amino]propanoic acid	non-polymer		495.6	1	Chemie (EDK)
3	A	CITRATE ANION	non-polymer		189.1	1	Chemie (FLC)
4	A	SODIUM ION	non-polymer		23.0	3	Chemie (NA)
5	A	GLYCEROL	non-polymer		92.1	1	Chemie (GOL)
6		water	water		18.0	185	Chemie (HOH)

Sequence modifications

A: 203 - 477 (UniProt: P37231)

PDB	External Database	Details
Met 181	-	initiating methionine
Ala 182	-	expression tag
His 183	-	expression tag
His 184	-	expression tag
His 185	-	expression tag
His 186	-	expression tag
His 187	-	expression tag
His 188	-	expression tag
Val 189	-	expression tag
Asp 190	-	expression tag
Asp 191	-	expression tag
Asp 192	-	expression tag
Asp 193	-	expression tag
Lys 194	-	expression tag
Met 195	-	expression tag
Glu 196	-	expression tag
Asn 197	-	expression tag
Leu 198	-	expression tag
Tyr 199	-	expression tag
Phe 200	-	expression tag
Gln 201	-	expression tag
Gly 202	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	34152.4
Non-Polymers*	Number of molecules	6
	Total formula weight	845.7
All*	Total formula weight	34998.2

*Water molecules are not included.