6D08
Crystal structure of an engineered bump-hole complex of mutant human chromobox homolog 1 (CBX1) with H3K9bn peptide
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, C (A, B) | Chromobox protein homolog 1 | polymer | 55 | 6390.1 | 2 | UniProt (P83916) Pfam (PF00385) | Homo sapiens (Human) | HP1Hsbeta, Heterochromatin protein 1 homolog beta, HP1 beta, Heterochromatin protein p25, M31, Modifier 1 protein, p25beta |
| 2 | B, D (C, D) | Histone H3.1 | polymer | 16 | 1652.9 | 2 | UniProt (P68431) | Homo sapiens | Histone H3/a, Histone H3/b, Histone H3/c, Histone H3/d, Histone H3/f, Histone H3/h, Histone H3/i, Histone H3/j, Histone H3/k, Histone H3/l |
| 3 | E, F, H, I (A, B) | GLYCEROL | non-polymer | 92.1 | 4 | Chemie (GOL) | |||
| 4 | G, J (C, D) | SULFATE ION | non-polymer | 96.1 | 2 | Chemie (SO4) | |||
| 5 | K, L, M, N (A, C, B, D) | water | water | 18.0 | 38 | Chemie (HOH) |
Sequence modifications
A, B: 2 - 55 (UniProt: P83916)
C, D: 1 - 15 (UniProt: P68431)
| PDB | External Database | Details |
|---|---|---|
| Gly 1 | - | expression tag |
| Phe 3 | Tyr 21 | engineered mutation |
| Gly 27 | Phe 45 | engineered mutation |
| PDB | External Database | Details |
|---|---|---|
| Nh2 16 | - | amidation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 16086.1 | |
| Non-Polymers* | Number of molecules | 6 |
| Total formula weight | 560.5 | |
| All* | Total formula weight | 16646.6 |
