6CZO

The KNL1-PP1 Holoenzyme

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, C (A, C)	Serine/threonine-protein phosphatase PP1-alpha catalytic subunit	polymer	299	34162.1	2	UniProt (P62136) Pfam (PF16891) Pfam (PF00149)	Homo sapiens (Human)	PP-1A
2	B, D (B, D)	CASC5 protein	polymer	62	6948.9	2	UniProt (Q05C46) UniProt (by SIFTS) (Q8NG31)	Homo sapiens (Human)
3	E, F, H, I (A, C)	MANGANESE (II) ION	non-polymer		54.9	4	Chemie (MN)
4	G, J (A, C)	PHOSPHATE ION	non-polymer		95.0	2	Chemie (PO4)
5	K, L, M, N (A, B, C, D)	water	water		18.0	60	Chemie (HOH)

Sequence modifications

A, C: 7 - 300 (UniProt: P62136)

PDB	External Database	Details
Gly 2	-	expression tag
His 3	-	expression tag
Met 4	-	expression tag
Gly 5	-	expression tag
Ser 6	-	expression tag

B, D: 23 - 80 (UniProt: Q05C46)

PDB	External Database	Details
Gly 19	-	expression tag
Ala 20	-	expression tag
Met 21	-	expression tag
Gly 22	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	82222.2
Non-Polymers*	Number of molecules	6
	Total formula weight	409.7
All*	Total formula weight	82631.9

*Water molecules are not included.