6CZO

The KNL1-PP1 Holoenzyme

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0016787	molecular_function	hydrolase activity
B	0008608	biological_process	attachment of spindle microtubules to kinetochore
B	0034501	biological_process	protein localization to kinetochore
C	0016787	molecular_function	hydrolase activity
D	0008608	biological_process	attachment of spindle microtubules to kinetochore
D	0034501	biological_process	protein localization to kinetochore

Functional Information from PDB Data

site_id	AC1
Number of Residues	7
Details	binding site for residue MN A 401

Chain	Residue
A	ASP64
A	HIS66
A	ASP92
A	MN402
A	PO4403
A	HOH501
A	HOH510

---

site_id	AC2
Number of Residues	7
Details	binding site for residue MN A 402

Chain	Residue
A	HIS173
A	HIS248
A	MN401
A	PO4403
A	HOH501
A	ASP92
A	ASN124

---

site_id	AC3
Number of Residues	13
Details	binding site for residue PO4 A 403

Chain	Residue
A	HIS66
A	ASP92
A	ARG96
A	ASN124
A	HIS125
A	ARG221
A	HIS248
A	TYR272
A	MN401
A	MN402
A	HOH501
A	HOH510
A	HOH522

---

site_id	AC4
Number of Residues	7
Details	binding site for residue MN C 401

Chain	Residue
C	ASP64
C	HIS66
C	ASP92
C	MN402
C	PO4403
C	HOH502
C	HOH510

---

site_id	AC5
Number of Residues	7
Details	binding site for residue MN C 402

Chain	Residue
C	ASP92
C	ASN124
C	HIS173
C	HIS248
C	MN401
C	PO4403
C	HOH502

---

site_id	AC6
Number of Residues	12
Details	binding site for residue PO4 C 403

Chain	Residue
C	HIS66
C	ASP92
C	ARG96
C	ASN124
C	HIS125
C	ARG221
C	HIS248
C	TYR272
C	MN401
C	MN402
C	HOH502
C	HOH510

---

Functional Information from PROSITE/UniProt

site_id	PS00125
Number of Residues	6
Details	SER_THR_PHOSPHATASE Serine/threonine specific protein phosphatases signature. LRGNHE

Chain	Residue	Details
A	LEU121-GLU126

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	Active site: {"description":"Proton donor","evidences":[{"source":"UniProtKB","id":"P36873","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	12
Details	Binding site: {"evidences":[{"source":"PubMed","id":"30100357","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"35830882","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"35831509","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"36175670","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"39446389","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6CZO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7TVF","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7TXH","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7UPI","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8SW5","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	2
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	2
Details	Modified residue: {"description":"Phosphoserine; by AURKB","evidences":[{"source":"PubMed","id":"30100357","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27697923","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	2
Details	Modified residue: {"description":"Phosphoserine; by AURKB","evidences":[{"source":"PubMed","id":"30100357","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18669648","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---