6CYT

HIV-1 TAR loop in complex with Tat:AFF4:P-TEFb

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	Cyclin-dependent kinase 9	polymer	332	38226.3	1	UniProt (P50750) Pfam (PF00069)	Homo sapiens (Human)	C-2K,Cell division cycle 2-like protein kinase 4,Cell division protein kinase 9,Serine/threonine-protein kinase PITALRE,Tat-associated kinase complex catalytic subunit
2	B (B)	Cyclin-T1	polymer	264	30619.0	1	UniProt (O60563) Pfam (PF00134) Pfam (PF21797)	Homo sapiens (Human)	Cyclin-T
3	C (C)	AF4/FMR2 family member 4	polymer	36	4164.7	1	UniProt (Q9UHB7)	Homo sapiens (Human)	ALL1-fused gene from chromosome 5q31 protein,Protein AF-5q31,Major CDK9 elongation factor-associated protein
4	D (D)	Protein Tat	polymer	58	6784.1	1	UniProt (A0A0C5HAL9) Pfam (PF00539) UniProt (by SIFTS) (P04608)	Human immunodeficiency virus 1
5	E (N)	RNA (5'-R(P*AP*UP*CP*UP*GP*AP*GP*CP*CP*UP*GP*GP*GP*AP*GP*CP*U)-3')	polymer	20	6438.9	1		Human immunodeficiency virus 1
6	F, G (D)	ZINC ION	non-polymer		65.4	2	Chemie (ZN)

Sequence modifications

A: 1 - 330 (UniProt: P50750)

PDB	External Database	Details
Gly -1	-	expression tag
His 0	-	expression tag

C: 32 - 67 (UniProt: Q9UHB7)

PDB	External Database	Details
Tyr 47	Lys 47	conflict

D: 1 - 57 (UniProt: A0A0C5HAL9)

PDB	External Database	Details
Ace 0	-	acetylation

Contents of the asymmetric unit

Polymers	Number of chains	5
	Total formula weight	86232.9
Non-Polymers*	Number of molecules	2
	Total formula weight	130.8
All*	Total formula weight	86363.7

*Water molecules are not included.