6CYT

HIV-1 TAR loop in complex with Tat:AFF4:P-TEFb

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004672	molecular_function	protein kinase activity
A	0005524	molecular_function	ATP binding
A	0006468	biological_process	protein phosphorylation
B	0006357	biological_process	regulation of transcription by RNA polymerase II
B	0016538	molecular_function	cyclin-dependent protein serine/threonine kinase regulator activity
C	0010468	biological_process	regulation of gene expression
D	0001070	molecular_function	RNA-binding transcription regulator activity
D	0042025	cellular_component	host cell nucleus
D	0050434	biological_process	positive regulation of viral transcription

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	binding site for residue ZN D 101

Chain	Residue
D	CYS22
D	HIS33
D	CYS34
D	CYS37

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site_id	AC2
Number of Residues	4
Details	binding site for residue ZN D 102

Chain	Residue
B	CYS261
D	CYS25
D	CYS27
D	CYS30

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Functional Information from PROSITE/UniProt

site_id	PS00107
Number of Residues	24
Details	PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. IGQGTFGEVFkArhrktgqk..........VALK

Chain	Residue	Details
A	ILE25-LYS48

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site_id	PS00108
Number of Residues	13
Details	PROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. IlHrDMKaaNVLI

Chain	Residue	Details
A	ILE145-ILE157

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	7
Details	BINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_04079, ECO:0000269|PubMed:20535204, ECO:0000269|PubMed:24727379

Chain	Residue	Details
D	CYS22
D	CYS25
D	CYS27
D	CYS30
D	HIS33
D	CYS34
D	CYS37

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site_id	SWS_FT_FI2
Number of Residues	1
Details	SITE: Essential for Tat translocation through the endosomal membrane => ECO:0000255|HAMAP-Rule:MF_04079

Chain	Residue	Details
D	TRP11

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site_id	SWS_FT_FI3
Number of Residues	1
Details	MOD_RES: N6-acetyllysine; by host PCAF => ECO:0000255|HAMAP-Rule:MF_04079

Chain	Residue	Details
D	LYS28
A	ASP104
A	ASP167

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site_id	SWS_FT_FI4
Number of Residues	2
Details	MOD_RES: N6-acetyllysine; by host EP300 and GCN5L2 => ECO:0000255|HAMAP-Rule:MF_04079, ECO:0000269|PubMed:18480452

Chain	Residue	Details
D	LYS50
D	LYS51

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site_id	SWS_FT_FI5
Number of Residues	2
Details	MOD_RES: Asymmetric dimethylarginine; by host PRMT6 => ECO:0000255|HAMAP-Rule:MF_04079, ECO:0000269|PubMed:17267505

Chain	Residue	Details
D	ARG52
D	ARG53

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site_id	SWS_FT_FI6
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0000269|PubMed:21533037

Chain	Residue	Details
A	SER175

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site_id	SWS_FT_FI7
Number of Residues	1
Details	MOD_RES: Phosphothreonine; by CaMK1D => ECO:0000269|PubMed:15965233, ECO:0000269|PubMed:18483222, ECO:0000269|PubMed:18566585, ECO:0000269|PubMed:18829461, ECO:0000269|PubMed:20535204, ECO:0000269|PubMed:20851342, ECO:0000269|PubMed:21448926, ECO:0000269|PubMed:21779453, ECO:0007744|PubMed:21406692

Chain	Residue	Details
A	TPO186

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