6CWU

Protein Tyrosine Phosphatase 1B F135Y mutant

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	Tyrosine-protein phosphatase non-receptor type 1	polymer	329	38452.8	1	UniProt (P18031) Pfam (PF00102) In PDB	Homo sapiens (Human)	Protein-tyrosine phosphatase 1B,PTP-1B
2	A	MAGNESIUM ION	non-polymer		24.3	1	Chemie (MG)
3		water	water		18.0	352	Chemie (HOH)

Sequence modifications

A: 1 - 321 (UniProt: P18031)

PDB	External Database	Details
Tyr 135	Phe 135	engineered mutation
Leu 322	-	expression tag
Glu 323	-	expression tag
His 324	-	expression tag
His 325	-	expression tag
His 326	-	expression tag
His 327	-	expression tag
His 328	-	expression tag
His 329	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	38452.8
Non-Polymers*	Number of molecules	1
	Total formula weight	24.3
All*	Total formula weight	38477.1

*Water molecules are not included.