6CS2
SARS Spike Glycoprotein - human ACE2 complex, Stabilized variant, all ACE2-bound particles
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C (A, B, C) | Spike glycoprotein,Fibritin | polymer | 1215 | 134739.3 | 3 | UniProt (P59594) UniProt (D9IEJ2) Pfam (PF16451) Pfam (PF09408) Pfam (PF01601) UniProt (by SIFTS) (P10104) | Human SARS coronavirus (SARS-CoV) | S glycoprotein,E2,Peplomer protein |
| 2 | D (D) | Angiotensin-converting enzyme 2 | polymer | 605 | 70027.7 | 1 | UniProt (Q9BYF1) Pfam (PF01401) | Homo sapiens (Human) | ACE-related carboxypeptidase,Angiotensin-converting enzyme homolog,ACEH,Metalloprotease MPROT15 |
| 3 | E, F, M, O, Q... (E, F, M, O, Q...) | beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 586.5 | 9 | In PDB GlyTouCan (G15407YE) | |||
| 4 | CA, G, J, N, R... (c, G, J, N, R...) | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 7 | In PDB GlyTouCan (G42666HT) | |||
| 5 | AA, BA, DA, EA, H... (a, b, d, e, H...) | alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 748.7 | 10 | In PDB GlyTouCan (G81315DD) | |||
| 6 | U (U) | alpha-D-mannopyranose-(1-6)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 748.7 | 1 | In PDB GlyTouCan (G22573RC) | |||
| 7 | FA, GA, HA, IA, JA... (A, B, C) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 6 | Chemie (NAG) |
Sequence modifications
A, B, C: 14 - 1190 (UniProt: P59594)
A, B, C: 1192 - 1219 (UniProt: D9IEJ2)
D: 19 - 615 (UniProt: Q9BYF1)
| PDB | External Database | Details |
|---|---|---|
| Ala 577 | Ser 577 | conflict |
| Pro 968 | Lys 968 | engineered mutation |
| Pro 969 | Val 969 | engineered mutation |
| Gly 1191 | - | linker |
| PDB | External Database | Details |
|---|---|---|
| Ser 1192 | Ala 457 | linker |
| Gly 1220 | - | expression tag |
| Arg 1221 | - | expression tag |
| Ser 1222 | - | expression tag |
| Leu 1223 | - | expression tag |
| Glu 1224 | - | expression tag |
| Val 1225 | - | expression tag |
| Leu 1226 | - | expression tag |
| Phe 1227 | - | expression tag |
| Gln 1228 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Gly 616 | - | expression tag |
| Ser 617 | - | expression tag |
| Leu 618 | - | expression tag |
| Glu 619 | - | expression tag |
| Val 620 | - | expression tag |
| Leu 621 | - | expression tag |
| Phe 622 | - | expression tag |
| Gln 623 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 474245.5 | |
| Branched | Number of molecules | 27 |
| Total formula weight | 16485.2 | |
| Non-Polymers* | Number of molecules | 6 |
| Total formula weight | 1327.2 | |
| All* | Total formula weight | 492057.9 |
