6CS2
SARS Spike Glycoprotein - human ACE2 complex, Stabilized variant, all ACE2-bound particles
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B, C | Spike glycoprotein,Fibritin | polymer | 1215 | 134739.3 | 3 | UniProt (P59594) UniProt (D9IEJ2) Pfam (PF16451) Pfam (PF09408) Pfam (PF19209) Pfam (PF01601) UniProt (by SIFTS) (P10104) In PDB | Human SARS coronavirus (SARS-CoV) | S glycoprotein,E2,Peplomer protein |
2 | D | Angiotensin-converting enzyme 2 | polymer | 605 | 70027.7 | 1 | UniProt (Q9BYF1) Pfam (PF01401) In PDB | Homo sapiens (Human) | ACE-related carboxypeptidase,Angiotensin-converting enzyme homolog,ACEH,Metalloprotease MPROT15 |
3 | E, F, M, O, Q... | beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 586.5 | 9 | In PDB GlyTouCan (G15407YE) | |||
4 | c, G, J, N, R... | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 7 | In PDB GlyTouCan (G42666HT) | |||
5 | a, b, d, e, H... | alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 748.7 | 10 | In PDB GlyTouCan (G81315DD) | |||
6 | U | alpha-D-mannopyranose-(1-6)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 748.7 | 1 | In PDB GlyTouCan (G22573RC) | |||
7 | A, B, C | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 6 | Chemie (NAG) |
Sequence modifications
A, B, C: 14 - 1190 (UniProt: P59594)
A, B, C: 1192 - 1219 (UniProt: D9IEJ2)
D: 19 - 615 (UniProt: Q9BYF1)
PDB | External Database | Details |
---|---|---|
Ala 577 | Ser 577 | conflict |
Pro 968 | Lys 968 | engineered mutation |
Pro 969 | Val 969 | engineered mutation |
Gly 1191 | - | linker |
PDB | External Database | Details |
---|---|---|
Ser 1192 | Ala 457 | linker |
Gly 1220 | - | expression tag |
Arg 1221 | - | expression tag |
Ser 1222 | - | expression tag |
Leu 1223 | - | expression tag |
Glu 1224 | - | expression tag |
Val 1225 | - | expression tag |
Leu 1226 | - | expression tag |
Phe 1227 | - | expression tag |
Gln 1228 | - | expression tag |
PDB | External Database | Details |
---|---|---|
Gly 616 | - | expression tag |
Ser 617 | - | expression tag |
Leu 618 | - | expression tag |
Glu 619 | - | expression tag |
Val 620 | - | expression tag |
Leu 621 | - | expression tag |
Phe 622 | - | expression tag |
Gln 623 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 4 |
Total formula weight | 474245.5 | |
Branched | Number of molecules | 27 |
Total formula weight | 16485.2 | |
Non-Polymers* | Number of molecules | 6 |
Total formula weight | 1327.2 | |
All* | Total formula weight | 492057.9 |