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6CS2

SARS Spike Glycoprotein - human ACE2 complex, Stabilized variant, all ACE2-bound particles

Functional Information from GO Data
ChainGOidnamespacecontents
A0005515molecular_functionprotein binding
A0016020cellular_componentmembrane
A0019031cellular_componentviral envelope
A0019049biological_processvirus-mediated perturbation of host defense response
A0019062biological_processvirion attachment to host cell
A0019064biological_processfusion of virus membrane with host plasma membrane
A0020002cellular_componenthost cell plasma membrane
A0033644cellular_componenthost cell membrane
A0039503biological_processobsolete suppression by virus of host innate immune response
A0039587biological_processsuppression by virus of host tetherin activity
A0039654biological_processfusion of virus membrane with host endosome membrane
A0039663biological_processmembrane fusion involved in viral entry into host cell
A0042802molecular_functionidentical protein binding
A0044173cellular_componenthost cell endoplasmic reticulum-Golgi intermediate compartment membrane
A0044423cellular_componentvirion component
A0046598biological_processpositive regulation of viral entry into host cell
A0046718biological_processsymbiont entry into host cell
A0046789molecular_functionhost cell surface receptor binding
A0046813biological_processreceptor-mediated virion attachment to host cell
A0055036cellular_componentvirion membrane
A0061025biological_processmembrane fusion
A0075509biological_processendocytosis involved in viral entry into host cell
B0005515molecular_functionprotein binding
B0016020cellular_componentmembrane
B0019031cellular_componentviral envelope
B0019049biological_processvirus-mediated perturbation of host defense response
B0019062biological_processvirion attachment to host cell
B0019064biological_processfusion of virus membrane with host plasma membrane
B0020002cellular_componenthost cell plasma membrane
B0033644cellular_componenthost cell membrane
B0039503biological_processobsolete suppression by virus of host innate immune response
B0039587biological_processsuppression by virus of host tetherin activity
B0039654biological_processfusion of virus membrane with host endosome membrane
B0039663biological_processmembrane fusion involved in viral entry into host cell
B0042802molecular_functionidentical protein binding
B0044173cellular_componenthost cell endoplasmic reticulum-Golgi intermediate compartment membrane
B0044423cellular_componentvirion component
B0046598biological_processpositive regulation of viral entry into host cell
B0046718biological_processsymbiont entry into host cell
B0046789molecular_functionhost cell surface receptor binding
B0046813biological_processreceptor-mediated virion attachment to host cell
B0055036cellular_componentvirion membrane
B0061025biological_processmembrane fusion
B0075509biological_processendocytosis involved in viral entry into host cell
C0005515molecular_functionprotein binding
C0016020cellular_componentmembrane
C0019031cellular_componentviral envelope
C0019049biological_processvirus-mediated perturbation of host defense response
C0019062biological_processvirion attachment to host cell
C0019064biological_processfusion of virus membrane with host plasma membrane
C0020002cellular_componenthost cell plasma membrane
C0033644cellular_componenthost cell membrane
C0039503biological_processobsolete suppression by virus of host innate immune response
C0039587biological_processsuppression by virus of host tetherin activity
C0039654biological_processfusion of virus membrane with host endosome membrane
C0039663biological_processmembrane fusion involved in viral entry into host cell
C0042802molecular_functionidentical protein binding
C0044173cellular_componenthost cell endoplasmic reticulum-Golgi intermediate compartment membrane
C0044423cellular_componentvirion component
C0046598biological_processpositive regulation of viral entry into host cell
C0046718biological_processsymbiont entry into host cell
C0046789molecular_functionhost cell surface receptor binding
C0046813biological_processreceptor-mediated virion attachment to host cell
C0055036cellular_componentvirion membrane
C0061025biological_processmembrane fusion
C0075509biological_processendocytosis involved in viral entry into host cell
D0006508biological_processproteolysis
D0008237molecular_functionmetallopeptidase activity
D0008241molecular_functionpeptidyl-dipeptidase activity
D0016020cellular_componentmembrane
Functional Information from PROSITE/UniProt
site_idPS00142
Number of Residues10
DetailsZINC_PROTEASE Neutral zinc metallopeptidases, zinc-binding region signature. TAHHEMGHIQ
ChainResidueDetails
DTHR371-GLN380

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues1
DetailsACT_SITE: Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU01355, ECO:0000305|PubMed:14754895, ECO:0000305|PubMed:27217402
ChainResidueDetails
DGLU375
AARG797
BARG667
BARG797
CARG667
CARG797

site_idSWS_FT_FI2
Number of Residues1
DetailsACT_SITE: Proton donor => ECO:0000255|PROSITE-ProRule:PRU01355, ECO:0000305|PubMed:14754895
ChainResidueDetails
DHIS505
AASN65
AASN73
AASN109
AASN118
AASN119
AASN158
AASN227
AASN269
AASN318
AASN330
AASN357
AASN589
AASN602
AASN691
AASN699
AASN783
AASN1056
AASN1080
AASN1116
AASN1140
AASN1155
AASN1176
BASN29
BASN65
BASN73
BASN109
BASN118
BASN119
BASN158
BASN227
BASN269
BASN318
BASN330
BASN357
BASN589
BASN602
BASN691
BASN699
BASN783
BASN1056
BASN1080
BASN1116
BASN1140
BASN1155
BASN1176
CASN29
CASN65
CASN73
CASN109
CASN118
CASN119
CASN158
CASN227
CASN269
CASN318
CASN330
CASN357
CASN589
CASN602
CASN691
CASN699
CASN783
CASN1056
CASN1080
CASN1116
CASN1140
CASN1155
CASN1176

site_idSWS_FT_FI3
Number of Residues3
DetailsBINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU01355, ECO:0000269|PubMed:14754895, ECO:0000305|PubMed:19021774
ChainResidueDetails
DARG169
DTRP477
DLYS481

site_idSWS_FT_FI4
Number of Residues3
DetailsBINDING: BINDING => ECO:0000305|PubMed:14754895
ChainResidueDetails
DARG273
DHIS345
DTYR515

site_idSWS_FT_FI5
Number of Residues3
DetailsBINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU01355, ECO:0000269|PubMed:14754895
ChainResidueDetails
DGLU402
DHIS374
DHIS378

site_idSWS_FT_FI6
Number of Residues2
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000305|PubMed:14754895
ChainResidueDetails
DASN53
DASN322

site_idSWS_FT_FI7
Number of Residues1
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:14754895, ECO:0000269|PubMed:15084671, ECO:0000269|PubMed:19901337
ChainResidueDetails
DASN90

site_idSWS_FT_FI8
Number of Residues2
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:14754895
ChainResidueDetails
DASN103
DASN432

site_idSWS_FT_FI9
Number of Residues1
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:14754895, ECO:0000269|PubMed:19159218, ECO:0000269|PubMed:19901337
ChainResidueDetails
DASN546

218500

PDB entries from 2024-04-17

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