6CER
Human pyruvate dehydrogenase complex E1 component V138M mutation
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, C, E, G (A, C, E, G) | Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial | polymer | 365 | 40746.6 | 4 | UniProt (P08559) Pfam (PF00676) | Homo sapiens (Human) | PDHE1-A type I |
| 2 | B, D, F, H (B, D, F, H) | Pyruvate dehydrogenase E1 component subunit beta, mitochondrial | polymer | 331 | 36085.4 | 4 | UniProt (P11177) Pfam (PF02779) Pfam (PF02780) | Homo sapiens (Human) | PDHE1-B |
| 3 | I, J, K, M (A, C, E, G) | THIAMINE DIPHOSPHATE | non-polymer | 425.3 | 4 | Chemie (TPP) | |||
| 4 | L, N (E, G) | MAGNESIUM ION | non-polymer | 24.3 | 2 | Chemie (MG) | |||
| 5 | O, P, Q, R, S... (A, B, C, D, E...) | water | water | 18.0 | 302 | Chemie (HOH) |
Sequence modifications
A, C, E, G: 1 - 361 (UniProt: P08559)
B, D, F, H: 1 - 329 (UniProt: P11177)
| PDB | External Database | Details |
|---|---|---|
| Met -3 | - | initiating methionine |
| Arg -2 | - | expression tag |
| Gly -1 | - | expression tag |
| Ser 0 | - | expression tag |
| Met 138 | Val 167 | engineered mutation |
| PDB | External Database | Details |
|---|---|---|
| Gly -1 | - | expression tag |
| Ser 0 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 8 |
| Total formula weight | 307328.0 | |
| Non-Polymers* | Number of molecules | 6 |
| Total formula weight | 1749.9 | |
| All* | Total formula weight | 309077.8 |
