Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

6CER

Human pyruvate dehydrogenase complex E1 component V138M mutation

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004738	molecular_function	pyruvate dehydrogenase activity
A	0004739	molecular_function	pyruvate dehydrogenase (acetyl-transferring) activity
A	0005515	molecular_function	protein binding
A	0005634	cellular_component	nucleus
A	0005730	cellular_component	nucleolus
A	0005739	cellular_component	mitochondrion
A	0005759	cellular_component	mitochondrial matrix
A	0006006	biological_process	glucose metabolic process
A	0006086	biological_process	acetyl-CoA biosynthetic process from pyruvate
A	0006090	biological_process	pyruvate metabolic process
A	0006099	biological_process	tricarboxylic acid cycle
A	0016491	molecular_function	oxidoreductase activity
A	0016624	molecular_function	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
A	0034604	molecular_function	pyruvate dehydrogenase (NAD+) activity
A	0043231	cellular_component	intracellular membrane-bounded organelle
A	0045254	cellular_component	pyruvate dehydrogenase complex
A	1902494	cellular_component	catalytic complex
B	0003824	molecular_function	catalytic activity
B	0004739	molecular_function	pyruvate dehydrogenase (acetyl-transferring) activity
B	0005515	molecular_function	protein binding
B	0005634	cellular_component	nucleus
B	0005654	cellular_component	nucleoplasm
B	0005739	cellular_component	mitochondrion
B	0005759	cellular_component	mitochondrial matrix
B	0006006	biological_process	glucose metabolic process
B	0006086	biological_process	acetyl-CoA biosynthetic process from pyruvate
B	0006099	biological_process	tricarboxylic acid cycle
B	0016491	molecular_function	oxidoreductase activity
B	0034604	molecular_function	pyruvate dehydrogenase (NAD+) activity
B	0045254	cellular_component	pyruvate dehydrogenase complex
C	0004738	molecular_function	pyruvate dehydrogenase activity
C	0004739	molecular_function	pyruvate dehydrogenase (acetyl-transferring) activity
C	0005515	molecular_function	protein binding
C	0005634	cellular_component	nucleus
C	0005730	cellular_component	nucleolus
C	0005739	cellular_component	mitochondrion
C	0005759	cellular_component	mitochondrial matrix
C	0006006	biological_process	glucose metabolic process
C	0006086	biological_process	acetyl-CoA biosynthetic process from pyruvate
C	0006090	biological_process	pyruvate metabolic process
C	0006099	biological_process	tricarboxylic acid cycle
C	0016491	molecular_function	oxidoreductase activity
C	0016624	molecular_function	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
C	0034604	molecular_function	pyruvate dehydrogenase (NAD+) activity
C	0043231	cellular_component	intracellular membrane-bounded organelle
C	0045254	cellular_component	pyruvate dehydrogenase complex
C	1902494	cellular_component	catalytic complex
D	0003824	molecular_function	catalytic activity
D	0004739	molecular_function	pyruvate dehydrogenase (acetyl-transferring) activity
D	0005515	molecular_function	protein binding
D	0005634	cellular_component	nucleus
D	0005654	cellular_component	nucleoplasm
D	0005739	cellular_component	mitochondrion
D	0005759	cellular_component	mitochondrial matrix
D	0006006	biological_process	glucose metabolic process
D	0006086	biological_process	acetyl-CoA biosynthetic process from pyruvate
D	0006099	biological_process	tricarboxylic acid cycle
D	0016491	molecular_function	oxidoreductase activity
D	0034604	molecular_function	pyruvate dehydrogenase (NAD+) activity
D	0045254	cellular_component	pyruvate dehydrogenase complex
E	0004738	molecular_function	pyruvate dehydrogenase activity
E	0004739	molecular_function	pyruvate dehydrogenase (acetyl-transferring) activity
E	0005515	molecular_function	protein binding
E	0005634	cellular_component	nucleus
E	0005730	cellular_component	nucleolus
E	0005739	cellular_component	mitochondrion
E	0005759	cellular_component	mitochondrial matrix
E	0006006	biological_process	glucose metabolic process
E	0006086	biological_process	acetyl-CoA biosynthetic process from pyruvate
E	0006090	biological_process	pyruvate metabolic process
E	0006099	biological_process	tricarboxylic acid cycle
E	0016491	molecular_function	oxidoreductase activity
E	0016624	molecular_function	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
E	0034604	molecular_function	pyruvate dehydrogenase (NAD+) activity
E	0043231	cellular_component	intracellular membrane-bounded organelle
E	0045254	cellular_component	pyruvate dehydrogenase complex
E	1902494	cellular_component	catalytic complex
F	0003824	molecular_function	catalytic activity
F	0004739	molecular_function	pyruvate dehydrogenase (acetyl-transferring) activity
F	0005515	molecular_function	protein binding
F	0005634	cellular_component	nucleus
F	0005654	cellular_component	nucleoplasm
F	0005739	cellular_component	mitochondrion
F	0005759	cellular_component	mitochondrial matrix
F	0006006	biological_process	glucose metabolic process
F	0006086	biological_process	acetyl-CoA biosynthetic process from pyruvate
F	0006099	biological_process	tricarboxylic acid cycle
F	0016491	molecular_function	oxidoreductase activity
F	0034604	molecular_function	pyruvate dehydrogenase (NAD+) activity
F	0045254	cellular_component	pyruvate dehydrogenase complex
G	0004738	molecular_function	pyruvate dehydrogenase activity
G	0004739	molecular_function	pyruvate dehydrogenase (acetyl-transferring) activity
G	0005515	molecular_function	protein binding
G	0005634	cellular_component	nucleus
G	0005730	cellular_component	nucleolus
G	0005739	cellular_component	mitochondrion
G	0005759	cellular_component	mitochondrial matrix
G	0006006	biological_process	glucose metabolic process
G	0006086	biological_process	acetyl-CoA biosynthetic process from pyruvate
G	0006090	biological_process	pyruvate metabolic process
G	0006099	biological_process	tricarboxylic acid cycle
G	0016491	molecular_function	oxidoreductase activity
G	0016624	molecular_function	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
G	0034604	molecular_function	pyruvate dehydrogenase (NAD+) activity
G	0043231	cellular_component	intracellular membrane-bounded organelle
G	0045254	cellular_component	pyruvate dehydrogenase complex
G	1902494	cellular_component	catalytic complex
H	0003824	molecular_function	catalytic activity
H	0004739	molecular_function	pyruvate dehydrogenase (acetyl-transferring) activity
H	0005515	molecular_function	protein binding
H	0005634	cellular_component	nucleus
H	0005654	cellular_component	nucleoplasm
H	0005739	cellular_component	mitochondrion
H	0005759	cellular_component	mitochondrial matrix
H	0006006	biological_process	glucose metabolic process
H	0006086	biological_process	acetyl-CoA biosynthetic process from pyruvate
H	0006099	biological_process	tricarboxylic acid cycle
H	0016491	molecular_function	oxidoreductase activity
H	0034604	molecular_function	pyruvate dehydrogenase (NAD+) activity
H	0045254	cellular_component	pyruvate dehydrogenase complex

Functional Information from PDB Data

site_id	AC1
Number of Residues	13
Details	binding site for residue TPP A 401

Chain	Residue
A	HIS63
D	ILE57
D	GLU59
D	MET81
D	PHE85
A	TYR89
A	ARG90
A	GLY136
A	MET138
A	ARG259
A	HOH503
D	GLU28
D	GLU29

site_id	AC2
Number of Residues	11
Details	binding site for residue TPP C 401

Chain	Residue
B	GLU28
B	ILE57
B	GLU59
B	MET81
B	PHE85
B	GLN88
C	TYR89
C	ARG90
C	GLY136
C	MET138
C	HOH510

site_id	AC3
Number of Residues	13
Details	binding site for residue TPP E 401

Chain	Residue
E	TYR89
E	ARG90
E	GLY136
E	MET138
E	ARG259
E	MG402
H	GLU28
H	GLU29
H	ILE57
H	GLU59
H	MET81
H	PHE85
H	GLN88

site_id	AC4
Number of Residues	3
Details	binding site for residue MG E 402

Chain	Residue
E	ARG90
E	ARG259
E	TPP401

site_id	AC5
Number of Residues	11
Details	binding site for residue TPP G 401

Chain	Residue
F	GLU28
F	ILE57
F	GLU59
F	MET81
F	PHE85
G	HIS63
G	TYR89
G	ARG90
G	GLY136
G	MET138
G	MG402

site_id	AC6
Number of Residues	1
Details	binding site for residue MG G 402

Chain	Residue
G	TPP401

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	BINDING: BINDING => ECO:0000269\|PubMed:12651851

Chain	Residue	Details
B	GLU59
G	LYS34
G	LYS215
G	LYS284
D	GLU59
F	GLU59
H	GLU59
C	LYS215
C	LYS284
E	LYS34
E	LYS215
E	LYS284

site_id	SWS_FT_FI2
Number of Residues	4
Details	SITE: Important for interaction with DLAT => ECO:0000269\|PubMed:20160912

Chain	Residue	Details
B	ASP289
D	ASP289
F	ASP289
H	ASP289

site_id	SWS_FT_FI3
Number of Residues	4
Details	MOD_RES: Phosphotyrosine => ECO:0000250\|UniProtKB:Q9D051

Chain	Residue	Details
B	TYR37
D	TYR37
F	TYR37
H	TYR37
E	LYS248
E	LYS356
G	LYS248
G	LYS356

site_id	SWS_FT_FI4
Number of Residues	4
Details	MOD_RES: N6-acetyllysine => ECO:0000250\|UniProtKB:Q9D051

Chain	Residue	Details
B	LYS324
D	LYS324
F	LYS324
H	LYS324

site_id	SWS_FT_FI5
Number of Residues	4
Details	MOD_RES: Phosphoserine => ECO:0000250\|UniProtKB:P35486

Chain	Residue	Details
A	SER266
C	SER266
E	SER266
G	SER266

site_id	SWS_FT_FI6
Number of Residues	4
Details	MOD_RES: Phosphoserine; by PDK1, PDK2, PDK3 and PDK4 => ECO:0000269\|PubMed:11486000, ECO:0000269\|PubMed:19081061

Chain	Residue	Details
A	SER271
C	SER271
E	SER271
G	SER271

site_id	SWS_FT_FI7
Number of Residues	4
Details	MOD_RES: Phosphotyrosine => ECO:0000250\|UniProtKB:P35486

Chain	Residue	Details
A	TYR272
C	TYR272
E	TYR272
G	TYR272

site_id	SWS_FT_FI8
Number of Residues	4
Details	MOD_RES: N6-acetyllysine => ECO:0007744\|PubMed:19608861

Chain	Residue	Details
A	LYS292
C	LYS292
E	LYS292
G	LYS292

site_id	SWS_FT_FI9
Number of Residues	4
Details	MOD_RES: N6-acetyllysine => ECO:0000250\|UniProtKB:P35486

Chain	Residue	Details
A	LYS307
C	LYS307
E	LYS307
G	LYS307

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)