6CBZ
Estrogen Receptor Alpha Ligand Binding Domain Y537S Mutant in Complex with Estradiol and GRIP Peptide
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Estrogen receptor | polymer | 250 | 28532.6 | 1 | UniProt (P03372) Pfam (PF00104) | Homo sapiens (Human) | ER,ER-alpha,Estradiol receptor,Nuclear receptor subfamily 3 group A member 1 |
| 2 | B (B) | Estrogen receptor | polymer | 250 | 28472.5 | 1 | UniProt (P03372) Pfam (PF00104) | Homo sapiens (Human) | ER,ER-alpha,Estradiol receptor,Nuclear receptor subfamily 3 group A member 1 |
| 3 | C, D (C, D) | grip peptide | polymer | 8 | 965.2 | 2 | Homo sapiens | ||
| 4 | E, G (A, B) | ESTRADIOL | non-polymer | 272.4 | 2 | Chemie (EST) PubChem (16757676) PubChem (1807201) PubChem (450) PubChem (177015577) PubChem (5757) PubChem (5998) PubChem (10596) PubChem (14880) PubChem (43912931) PubChem (44284023) PubChem (68570) PubChem (46781508) PubChem (54403267) PubChem (56624791) PubChem (57041922) PubChem (58650893) PubChem (59084698) PubChem (1807200) PubChem (68014581) PubChem (68209947) PubChem (70220248) PubChem (70864205) PubChem (667480) PubChem (667515) PubChem (721867) PubChem (928284) PubChem (1258565) PubChem (5317221) PubChem (91740223) PubChem (5317222) PubChem (5745505) PubChem (6328313) PubChem (6432565) PubChem (6560352) PubChem (6603846) PubChem (101691329) PubChem (6918968) PubChem (6919041) PubChem (7000012) PubChem (7004689) PubChem (7048584) PubChem (7048670) PubChem (118548795) PubChem (7061189) PubChem (7067800) PubChem (9795489) PubChem (9811784) PubChem (9903595) PubChem (9938293) PubChem (12313788) PubChem (11869602) PubChem (11870431) PubChem (12313787) PubChem (12313791) PubChem (12313794) PubChem (162947701) PubChem (166849971) PubChem (126969992) PubChem (129010410) PubChem (129317336) PubChem (130307439) PubChem (130307440) PubChem (143489158) PubChem (144605119) PubChem (145157829) PubChem (145610824) PubChem (154109755) PubChem (172873304) | |||
| 5 | F (B) | GLYCEROL | non-polymer | 92.1 | 1 | Chemie (GOL) PubChem (753) | |||
| 6 | H, I, J, K (A, B, C, D) | water | water | 18.0 | 511 | Chemie (HOH) |
Sequence modifications
A: 305 - 554 (UniProt: P03372)
B: 305 - 554 (UniProt: P03372)
| PDB | External Database | Details |
|---|---|---|
| Ser 537 | Tyr 537 | engineered mutation |
| PDB | External Database | Details |
|---|---|---|
| Ala 308 | Leu 308 | conflict |
| Met 417 | Cys 417 | conflict |
| Ser 537 | Tyr 537 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 58935.6 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 636.9 | |
| All* | Total formula weight | 59572.4 |
