6CBZ
Estrogen Receptor Alpha Ligand Binding Domain Y537S Mutant in Complex with Estradiol and GRIP Peptide
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | Estrogen receptor | polymer | 250 | 28532.6 | 1 | UniProt (P03372) Pfam (PF00104) In PDB | Homo sapiens (Human) | ER,ER-alpha,Estradiol receptor,Nuclear receptor subfamily 3 group A member 1 |
| 2 | B | Estrogen receptor | polymer | 250 | 28472.5 | 1 | UniProt (P03372) Pfam (PF00104) In PDB | Homo sapiens (Human) | ER,ER-alpha,Estradiol receptor,Nuclear receptor subfamily 3 group A member 1 |
| 3 | C, D | grip peptide | polymer | 8 | 965.2 | 2 | Homo sapiens | ||
| 4 | A, B | ESTRADIOL | non-polymer | 272.4 | 2 | Chemie (EST) | |||
| 5 | B | GLYCEROL | non-polymer | 92.1 | 1 | Chemie (GOL) | |||
| 6 | water | water | 18.0 | 511 | Chemie (HOH) |
Sequence modifications
A: 305 - 554 (UniProt: P03372)
B: 305 - 554 (UniProt: P03372)
| PDB | External Database | Details |
|---|---|---|
| Ser 537 | Tyr 537 | engineered mutation |
| PDB | External Database | Details |
|---|---|---|
| Ala 308 | Leu 308 | conflict |
| Met 417 | Cys 417 | conflict |
| Ser 537 | Tyr 537 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 58935.6 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 636.9 | |
| All* | Total formula weight | 59572.4 |
