6C90

Human Mtr4 helicase in complex with ZCCHC8-CTD

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	Exosome RNA helicase MTR4,Exosome RNA helicase MTR4	polymer	734	83205.8	1	UniProt (P42285) Pfam (PF00270) Pfam (PF00271) Pfam (PF08148) In PDB	Homo sapiens (Human)	ATP-dependent RNA helicase DOB1,ATP-dependent RNA helicase SKIV2L2,Superkiller viralicidic activity 2-like 2,TRAMP-like complex helicase
2	B	Zinc finger CCHC domain-containing protein 8	polymer	52	5870.6	1	UniProt (Q6NZY4) In PDB	Homo sapiens (Human)	TRAMP-like complex RNA-binding factor ZCCHC8
3	A	ADENOSINE-5'-DIPHOSPHATE	non-polymer		427.2	1	Chemie (ADP)
4	A	MAGNESIUM ION	non-polymer		24.3	2	Chemie (MG)
5	A	MALONATE ION	non-polymer		102.0	4	Chemie (MLI)
6	A	L(+)-TARTARIC ACID	non-polymer		150.1	1	Chemie (TLA)
7		water	water		18.0	238	Chemie (HOH)

Sequence modifications

A: 71 - 600 (UniProt: P42285)

PDB	External Database	Details
Ser 68	-	expression tag
Gly 69	-	expression tag
Asp 70	-	expression tag

A: 601 - 1042 (UniProt: P42285)

PDB	External Database	Details
Ser 601	Ala 842	linker

B: 659 - 707 (UniProt: Q6NZY4)

PDB	External Database	Details
Ser 656	-	expression tag
Gly 657	-	expression tag
Asp 658	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	89076.4
Non-Polymers*	Number of molecules	8
	Total formula weight	1034.1
All*	Total formula weight	90110.5

*Water molecules are not included.