6C90
Human Mtr4 helicase in complex with ZCCHC8-CTD
Functional Information from GO Data
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 12 |
| Details | binding site for residue ADP A 1101 |
| Chain | Residue |
| A | PHE138 |
| A | ASN490 |
| A | ARG527 |
| A | HOH1295 |
| A | ILE139 |
| A | ASP141 |
| A | GLN144 |
| A | THR163 |
| A | SER164 |
| A | GLY166 |
| A | LYS167 |
| A | THR168 |
| site_id | AC2 |
| Number of Residues | 2 |
| Details | binding site for residue MG A 1102 |
| Chain | Residue |
| A | TLA1108 |
| A | HOH1347 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | binding site for residue MG A 1103 |
| Chain | Residue |
| A | LEU573 |
| A | LEU574 |
| A | VAL576 |
| A | ILE579 |
| A | HOH1379 |
| A | HOH1399 |
| site_id | AC4 |
| Number of Residues | 5 |
| Details | binding site for residue MLI A 1104 |
| Chain | Residue |
| A | ARG854 |
| A | GLU952 |
| A | HOH1221 |
| A | HOH1230 |
| A | HOH1287 |
| site_id | AC5 |
| Number of Residues | 6 |
| Details | binding site for residue MLI A 1105 |
| Chain | Residue |
| A | ILE191 |
| A | LYS192 |
| A | ALA193 |
| A | ARG262 |
| A | ARG999 |
| A | HOH1223 |
| site_id | AC6 |
| Number of Residues | 6 |
| Details | binding site for residue MLI A 1106 |
| Chain | Residue |
| A | LYS396 |
| A | HIS456 |
| A | GLY457 |
| A | THR482 |
| A | THR484 |
| A | HOH1203 |
| site_id | AC7 |
| Number of Residues | 3 |
| Details | binding site for residue MLI A 1107 |
| Chain | Residue |
| A | LEU123 |
| A | LYS126 |
| A | HOH1244 |
| site_id | AC8 |
| Number of Residues | 4 |
| Details | binding site for residue TLA A 1108 |
| Chain | Residue |
| A | GLU113 |
| A | ILE286 |
| A | PRO287 |
| A | MG1102 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 156 |
| Details | Domain: {"description":"Helicase ATP-binding","evidences":[{"source":"PROSITE-ProRule","id":"PRU00541","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 172 |
| Details | Domain: {"description":"Helicase C-terminal","evidences":[{"source":"PROSITE-ProRule","id":"PRU00542","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 3 |
| Details | Motif: {"description":"DEIH box"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"31358741","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6RO1","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 7 |
| Details | Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00541","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 4 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"29844170","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"31358741","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6C90","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6RO1","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
