6C78

Substrate Binding Induces Conformational Changes In A Class A Beta Lactamase That Primes It For Catalysis

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	Beta-lactamase Toho-1	polymer	261	28045.7	1	UniProt (Q47066) Pfam (PF00144) Pfam (PF00905) Pfam (PF13354)	Escherichia coli
2	B (A)	water	water		18.0	101	Chemie (DOD)

Sequence modifications

A: 28 - 290 (UniProt: Q47066)

PDB	External Database	Details
Ala 27	-	expression tag
Ala 70	Ser 73	conflict
Asn 274	Arg 275	conflict
Asn 276	Arg 277	conflict

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	28045.7
All*	Total formula weight	28045.7

*Water molecules are not included.