6C42

Estrogen Receptor Alpha Ligand Binding Domain in Complex with OP1156

Replaces:  5UF9

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B	Estrogen receptor	polymer	249	28355.2	2	UniProt (P03372) Pfam (PF00104) In PDB	Homo sapiens (Human)	ER,ER-alpha,Estradiol receptor,Nuclear receptor subfamily 3 group A member 1
2	A, B	(2R,3S,4R)-3-(4-hydroxyphenyl)-4-methyl-2-{4-[2-(pyrrolidin-1-yl)ethoxy]phenyl}-3,4-dihydro-2H-1-benzopyran-7-ol	non-polymer		445.6	2	Chemie (85M)
3		water	water		18.0	430	Chemie (HOH)

Sequence modifications

A, B: 306 - 554 (UniProt: P03372)

PDB	External Database	Details
Ser 381	Cys 381	engineered mutation
Ser 417	Cys 417	engineered mutation
Ser 530	Cys 530	engineered mutation
Ser 536	Leu 536	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	56710.4
Non-Polymers*	Number of molecules	2
	Total formula weight	891.1
All*	Total formula weight	57601.5

*Water molecules are not included.