6C0V
Molecular structure of human P-glycoprotein in the ATP-bound, outward-facing conformation
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Multidrug resistance protein 1 | polymer | 1289 | 142660.9 | 1 | UniProt (P08183) Pfam (PF00664) Pfam (PF00005) | Homo sapiens (Human) | ATP-binding cassette sub-family B member 1,P-glycoprotein 1 |
| 2 | B, C (A) | ADENOSINE-5'-TRIPHOSPHATE | non-polymer | 507.2 | 2 | Chemie (ATP) | |||
| 3 | D, E (A) | MAGNESIUM ION | non-polymer | 24.3 | 2 | Chemie (MG) |
Sequence modifications
A: 1 - 1280 (UniProt: P08183)
| PDB | External Database | Details |
|---|---|---|
| Gln 556 | Glu 556 | engineered mutation |
| Gln 1201 | Glu 1201 | engineered mutation |
| Ser 1281 | - | expression tag |
| Asn 1282 | - | expression tag |
| Ser 1283 | - | expression tag |
| Leu 1284 | - | expression tag |
| Glu 1285 | - | expression tag |
| Val 1286 | - | expression tag |
| Leu 1287 | - | expression tag |
| Phe 1288 | - | expression tag |
| Gln 1289 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 142660.9 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 1063.0 | |
| All* | Total formula weight | 143723.9 |
