6C0V
Molecular structure of human P-glycoprotein in the ATP-bound, outward-facing conformation
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000086 | biological_process | G2/M transition of mitotic cell cycle |
| A | 0005515 | molecular_function | protein binding |
| A | 0005524 | molecular_function | ATP binding |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0006805 | biological_process | xenobiotic metabolic process |
| A | 0006869 | biological_process | lipid transport |
| A | 0008559 | molecular_function | ABC-type xenobiotic transporter activity |
| A | 0009410 | biological_process | response to xenobiotic stimulus |
| A | 0009986 | cellular_component | cell surface |
| A | 0015562 | molecular_function | efflux transmembrane transporter activity |
| A | 0016020 | cellular_component | membrane |
| A | 0016324 | cellular_component | apical plasma membrane |
| A | 0016887 | molecular_function | ATP hydrolysis activity |
| A | 0022857 | molecular_function | transmembrane transporter activity |
| A | 0031625 | molecular_function | ubiquitin protein ligase binding |
| A | 0042626 | molecular_function | ATPase-coupled transmembrane transporter activity |
| A | 0042910 | molecular_function | xenobiotic transmembrane transporter activity |
| A | 0045332 | biological_process | phospholipid translocation |
| A | 0046865 | biological_process | terpenoid transport |
| A | 0046943 | molecular_function | carboxylic acid transmembrane transporter activity |
| A | 0055085 | biological_process | transmembrane transport |
| A | 0070062 | cellular_component | extracellular exosome |
| A | 0070633 | biological_process | transepithelial transport |
| A | 0072089 | biological_process | stem cell proliferation |
| A | 0090554 | molecular_function | phosphatidylcholine floppase activity |
| A | 0090555 | molecular_function | phosphatidylethanolamine flippase activity |
| A | 0098591 | cellular_component | external side of apical plasma membrane |
| A | 0099038 | molecular_function | ceramide floppase activity |
| A | 0099040 | biological_process | ceramide translocation |
| A | 0140115 | biological_process | export across plasma membrane |
| A | 0140326 | molecular_function | ATPase-coupled intramembrane lipid transporter activity |
| A | 0140328 | molecular_function | floppase activity |
| A | 0140359 | molecular_function | ABC-type transporter activity |
| A | 0150104 | biological_process | transport across blood-brain barrier |
| A | 1905039 | biological_process | carboxylic acid transmembrane transport |
| A | 1990961 | biological_process | xenobiotic detoxification by transmembrane export across the plasma membrane |
| A | 1990962 | biological_process | xenobiotic transport across blood-brain barrier |
| A | 2001225 | biological_process | regulation of chloride transport |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 17 |
| Details | binding site for residue ATP A 1301 |
| Chain | Residue |
| A | ASP164 |
| A | THR435 |
| A | GLN475 |
| A | ARG905 |
| A | GLN1175 |
| A | SER1177 |
| A | GLY1179 |
| A | GLN1180 |
| A | MG1304 |
| A | TYR401 |
| A | ARG404 |
| A | ILE409 |
| A | SER429 |
| A | GLY430 |
| A | GLY432 |
| A | LYS433 |
| A | SER434 |
| site_id | AC2 |
| Number of Residues | 16 |
| Details | binding site for residue ATP A 1302 |
| Chain | Residue |
| A | GLN530 |
| A | SER532 |
| A | GLY533 |
| A | GLY534 |
| A | GLN535 |
| A | TYR1044 |
| A | THR1046 |
| A | ARG1047 |
| A | SER1072 |
| A | GLY1073 |
| A | GLY1075 |
| A | LYS1076 |
| A | SER1077 |
| A | THR1078 |
| A | GLN1118 |
| A | MG1303 |
| site_id | AC3 |
| Number of Residues | 3 |
| Details | binding site for residue MG A 1303 |
| Chain | Residue |
| A | SER1077 |
| A | GLN1118 |
| A | ATP1302 |
| site_id | AC4 |
| Number of Residues | 3 |
| Details | binding site for residue MG A 1304 |
| Chain | Residue |
| A | SER434 |
| A | GLN475 |
| A | ATP1301 |
Functional Information from PROSITE/UniProt
| site_id | PS00211 |
| Number of Residues | 15 |
| Details | ABC_TRANSPORTER_1 ABC transporters family signature. LSGGQKQRIAIARAL |
| Chain | Residue | Details |
| A | LEU531-LEU545 | |
| A | LEU1176-LEU1190 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 901 |
| Details | TOPO_DOM: Cytoplasmic => ECO:0000250 |
| Chain | Residue | Details |
| A | MET1-ASN44 | |
| A | LEU138-ILE186 | |
| A | SER237-ALA292 | |
| A | GLU353-PHE711 | |
| A | GLY778-ARG832 | |
| A | GLU875-LYS934 | |
| A | PRO996-GLN1280 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 249 |
| Details | TRANSMEM: Helical => ECO:0000255|PROSITE-ProRule:PRU00441 |
| Chain | Residue | Details |
| A | TRP45-LEU67 | |
| A | TRP855-VAL874 | |
| A | ALA935-PHE957 | |
| A | VAL974-ALA995 | |
| A | TYR117-CYS137 | |
| A | GLY187-PHE208 | |
| A | LEU216-LEU236 | |
| A | ILE293-TYR316 | |
| A | VAL331-ILE352 | |
| A | VAL712-PHE732 | |
| A | LEU757-PHE777 | |
| A | LEU833-TYR853 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 106 |
| Details | TOPO_DOM: Extracellular => ECO:0000250 |
| Chain | Residue | Details |
| A | MET68-TYR116 | |
| A | THR209-THR215 | |
| A | GLY317-GLN330 | |
| A | SER733-SER756 | |
| A | GLY854 | |
| A | ARG958-ASP973 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00434 |
| Chain | Residue | Details |
| A | GLY427 | |
| A | GLY1070 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P06795 |
| Chain | Residue | Details |
| A | SER660 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 3 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255 |
| Chain | Residue | Details |
| A | ASN91 | |
| A | ASN94 | |
| A | ASN99 |
