6BWJ

Crystal structure of the TRPV2 ion channel in complex with RTx

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Transient receptor potential cation channel subfamily V member 2	polymer	776	87605.4	2	UniProt (G1SNM3) Pfam (PF12796) Pfam (PF00520)	Oryctolagus cuniculus (Rabbit)
2	C, F (A, B)	resiniferatoxin	non-polymer		628.7	2	Chemie (6EU)
3	D, E (B)	CALCIUM ION	non-polymer		40.1	2	Chemie (CA)

Sequence modifications

A, B: 2 - 762 (UniProt: G1SNM3)

PDB	External Database	Details
Ser 470	Phe 525	engineered mutation
Met 505	Leu 560	engineered mutation
Thr 508	Leu 563	engineered mutation
Glu 528	Gln 583	engineered mutation
Asp 763	-	expression tag
Tyr 764	-	expression tag
Lys 765	-	expression tag
Asp 766	-	expression tag
Asp 767	-	expression tag
Asp 768	-	expression tag
Asp 769	-	expression tag
Lys 770	-	expression tag
Ala 771	-	expression tag
His 772	-	expression tag
His 773	-	expression tag
His 774	-	expression tag
His 775	-	expression tag
His 776	-	expression tag
His 777	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	175210.8
Non-Polymers*	Number of molecules	4
	Total formula weight	1337.6
All*	Total formula weight	176548.4

*Water molecules are not included.