6BS0
JAK2 JH2 in complex with 63552444
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Tyrosine-protein kinase JAK2 | polymer | 289 | 33121.0 | 1 | UniProt (O60674) Pfam (PF07714) | Homo sapiens (Human) | Janus kinase 2,JAK-2 |
| 2 | B (A) | 4-(5-aminopyrazin-2-yl)-1H-pyrrolo[2,3-b]pyridin-6-amine | non-polymer | 226.2 | 1 | Chemie (E4V) | |||
| 3 | C, D, E (A) | GLYCEROL | non-polymer | 92.1 | 3 | Chemie (GOL) | |||
| 4 | F (A) | water | water | 18.0 | 302 | Chemie (HOH) |
Sequence modifications
A: 536 - 812 (UniProt: O60674)
| PDB | External Database | Details |
|---|---|---|
| Ala 659 | Trp 659 | engineered mutation |
| Ala 777 | Trp 777 | engineered mutation |
| His 794 | Phe 794 | engineered mutation |
| Leu 813 | - | expression tag |
| Val 814 | - | expression tag |
| Pro 815 | - | expression tag |
| Arg 816 | - | expression tag |
| Gly 817 | - | expression tag |
| Ser 818 | - | expression tag |
| His 819 | - | expression tag |
| His 820 | - | expression tag |
| His 821 | - | expression tag |
| His 822 | - | expression tag |
| His 823 | - | expression tag |
| His 824 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 33121.0 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 502.5 | |
| All* | Total formula weight | 33623.5 |
