6BRR
Crystal structure of DNMT3A (R836A)-DNMT3L in complex with DNA containing two CpG sites
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, C (A, D) | DNA (cytosine-5)-methyltransferase 3A | polymer | 285 | 32629.6 | 2 | UniProt (Q9Y6K1) Pfam (PF00145) | Homo sapiens (Human) | Dnmt3a,DNA methyltransferase HsaIIIA,M.HsaIIIA |
| 2 | B, D (B, C) | DNA (cytosine-5)-methyltransferase 3-like | polymer | 209 | 24163.7 | 2 | UniProt (Q9UJW3) | Homo sapiens (Human) | |
| 3 | E, F (E, F) | DNA (25-MER) | polymer | 25 | 7699.0 | 2 | Homo sapiens | ||
| 4 | G, H (A, D) | S-ADENOSYL-L-HOMOCYSTEINE | non-polymer | 384.4 | 2 | Chemie (SAH) |
Sequence modifications
A, D: 628 - 912 (UniProt: Q9Y6K1)
B, C: 178 - 386 (UniProt: Q9UJW3)
| PDB | External Database | Details |
|---|---|---|
| Ala 836 | Arg 647 | engineered mutation |
| PDB | External Database | Details |
|---|---|---|
| - | Ser 332 | see remark 999 |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 6 |
| Total formula weight | 128984.6 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 768.8 | |
| All* | Total formula weight | 129753.4 |
