6BRR

Crystal structure of DNMT3A (R836A)-DNMT3L in complex with DNA containing two CpG sites

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0008168	molecular_function	methyltransferase activity
D	0008168	molecular_function	methyltransferase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	17
Details	binding site for residue SAH A 1001

Chain	Residue
A	PHE640
A	ASP686
A	VAL687
A	GLY707
A	PRO709
A	LEU730
A	ARG891
A	SER892
A	TRP893
A	ASP641
A	GLY642
A	ILE643
A	THR645
A	SER663
A	GLU664
A	VAL665
A	CYS666

---

site_id	AC2
Number of Residues	17
Details	binding site for residue SAH D 1001

Chain	Residue
D	PHE640
D	ASP641
D	GLY642
D	ILE643
D	THR645
D	SER663
D	GLU664
D	VAL665
D	CYS666
D	ASP686
D	VAL687
D	GLY707
D	PRO709
D	LEU730
D	ARG891
D	SER892
D	TRP893

---

site_id	AC3
Number of Residues	18
Details	binding site for Di-nucleotide DG E 426 and PYO E 427

Chain	Residue
D	SER708
D	CYS710
D	SER714
D	ILE715
D	VAL716
D	GLU756
D	VAL758
D	ARG790
D	ARG792
D	ARG831
D	THR832
D	GLY890
D	ARG891
E	DT425
E	DG428
F	DG442
F	DC443
F	DA444

---

site_id	AC4
Number of Residues	19
Details	binding site for Di-nucleotide PYO E 427 and DG E 428

Chain	Residue
D	SER708
D	CYS710
D	ASN711
D	SER714
D	VAL716
D	ASN717
D	PRO718
D	GLU756
D	VAL758
D	ARG790
D	ARG792
D	THR834
D	THR835
D	GLY890
D	ARG891
E	DG426
E	DT429
F	DA440
F	DC441

---

site_id	AC5
Number of Residues	18
Details	binding site for Di-nucleotide DG F 426 and PYO F 427

Chain	Residue
A	SER708
A	CYS710
A	SER714
A	ILE715
A	VAL716
A	GLU756
A	VAL758
A	ALA760
A	ARG790
A	ARG792
A	THR832
A	GLY890
A	ARG891
E	DG442
E	DC443
E	DA444
F	DT425
F	DG428

---

site_id	AC6
Number of Residues	20
Details	binding site for Di-nucleotide PYO F 427 and DG F 428

Chain	Residue
A	ARG790
A	ARG792
A	THR835
A	GLY890
A	ARG891
E	DA440
E	DC441
E	DG442
F	DG426
F	DT429
A	SER708
A	CYS710
A	ASN711
A	SER714
A	VAL716
A	ASN717
A	PRO718
A	GLU756
A	VAL758
A	ALA760

---

Functional Information from PROSITE/UniProt

site_id	PS00094
Number of Residues	13
Details	C5_MTASE_1 C-5 cytosine-specific DNA methylases active site. DlVigGsPCnDLS

Chain	Residue	Details
A	ASP702-SER714

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	60
Details	ZN_FING: GATA-type; atypical => ECO:0000255|PROSITE-ProRule:PRU00865

Chain	Residue	Details
A	MET682-ASP712
D	MET682-ASP712

---

site_id	SWS_FT_FI2
Number of Residues	112
Details	ZN_FING: PHD-type; atypical => ECO:0000255|PROSITE-ProRule:PRU00865

Chain	Residue	Details
A	LEU723-MET779
D	LEU723-MET779

---

site_id	SWS_FT_FI3
Number of Residues	2
Details	ACT_SITE: ACT_SITE => ECO:0000255|PROSITE-ProRule:PRU01016, ECO:0000255|PROSITE-ProRule:PRU10018

Chain	Residue	Details
A	ARG899
D	ARG899

---

site_id	SWS_FT_FI4
Number of Residues	6
Details	BINDING: BINDING => ECO:0000269|PubMed:17713477, ECO:0007744|PDB:2QRV

Chain	Residue	Details
A	VAL830
A	ASN853
A	THR875
D	VAL830
D	ASN853
D	THR875

---

site_id	SWS_FT_FI5
Number of Residues	2
Details	MOD_RES: S-methylcysteine; by autocatalysis => ECO:0000250|UniProtKB:O88508

Chain	Residue	Details
A	ARG899
D	ARG899

---