6BFQ

The mechanism of GM-CSF inhibition by human GM-CSF auto-antibodies

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, C, E, G (H, A, C, E)	Fab Heavy chain	polymer	225	23877.7	4		Homo sapiens
2	B, D, F, H (L, B, D, F)	Fab Light Chain	polymer	215	23494.3	4		Homo sapiens
3	I, J, K, L (G, J, I, K)	Granulocyte-macrophage colony-stimulating factor	polymer	127	14492.5	4	UniProt (P04141) Pfam (PF01109)	Homo sapiens (Human)	GM-CSF,Colony-stimulating factor,CSF,Molgramostin,Sargramostim
4	M, N, O, P, Q... (H, L, A, B, C...)	water	water		18.0	193	Chemie (HOH)

Contents of the asymmetric unit

Polymers	Number of chains	12
	Total formula weight	247457.8
All*	Total formula weight	247457.8

*Water molecules are not included.