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6BFQ

The mechanism of GM-CSF inhibition by human GM-CSF auto-antibodies

Functional Information from GO Data
ChainGOidnamespacecontents
G0001821biological_processhistamine secretion
G0001892biological_processembryonic placenta development
G0005125molecular_functioncytokine activity
G0005129molecular_functiongranulocyte macrophage colony-stimulating factor receptor binding
G0005515molecular_functionprotein binding
G0005576cellular_componentextracellular region
G0005615cellular_componentextracellular space
G0005886cellular_componentplasma membrane
G0006955biological_processimmune response
G0007165biological_processsignal transduction
G0007259biological_processcell surface receptor signaling pathway via JAK-STAT
G0008083molecular_functiongrowth factor activity
G0008283biological_processcell population proliferation
G0008284biological_processpositive regulation of cell population proliferation
G0009966biological_processregulation of signal transduction
G0010468biological_processregulation of gene expression
G0010628biological_processpositive regulation of gene expression
G0010744biological_processpositive regulation of macrophage derived foam cell differentiation
G0030099biological_processmyeloid cell differentiation
G0030223biological_processneutrophil differentiation
G0030224biological_processmonocyte differentiation
G0030225biological_processmacrophage differentiation
G0030335biological_processpositive regulation of cell migration
G0030526cellular_componentgranulocyte macrophage colony-stimulating factor receptor complex
G0032747biological_processpositive regulation of interleukin-23 production
G0034021biological_processresponse to silicon dioxide
G0034405biological_processresponse to fluid shear stress
G0038157biological_processgranulocyte-macrophage colony-stimulating factor signaling pathway
G0042045biological_processepithelial fluid transport
G0042127biological_processregulation of cell population proliferation
G0043011biological_processmyeloid dendritic cell differentiation
G0045187biological_processregulation of circadian sleep/wake cycle, sleep
G0045892biological_processnegative regulation of DNA-templated transcription
G0050793biological_processregulation of developmental process
G0070665biological_processpositive regulation of leukocyte proliferation
G0071222biological_processcellular response to lipopolysaccharide
G0071803biological_processpositive regulation of podosome assembly
G0097011biological_processcellular response to granulocyte macrophage colony-stimulating factor stimulus
G0097028biological_processdendritic cell differentiation
G0097696biological_processcell surface receptor signaling pathway via STAT
G2001240biological_processnegative regulation of extrinsic apoptotic signaling pathway in absence of ligand
I0001821biological_processhistamine secretion
I0001892biological_processembryonic placenta development
I0005125molecular_functioncytokine activity
I0005129molecular_functiongranulocyte macrophage colony-stimulating factor receptor binding
I0005515molecular_functionprotein binding
I0005576cellular_componentextracellular region
I0005615cellular_componentextracellular space
I0005886cellular_componentplasma membrane
I0006955biological_processimmune response
I0007165biological_processsignal transduction
I0007259biological_processcell surface receptor signaling pathway via JAK-STAT
I0008083molecular_functiongrowth factor activity
I0008283biological_processcell population proliferation
I0008284biological_processpositive regulation of cell population proliferation
I0009966biological_processregulation of signal transduction
I0010468biological_processregulation of gene expression
I0010628biological_processpositive regulation of gene expression
I0010744biological_processpositive regulation of macrophage derived foam cell differentiation
I0030099biological_processmyeloid cell differentiation
I0030223biological_processneutrophil differentiation
I0030224biological_processmonocyte differentiation
I0030225biological_processmacrophage differentiation
I0030335biological_processpositive regulation of cell migration
I0030526cellular_componentgranulocyte macrophage colony-stimulating factor receptor complex
I0032747biological_processpositive regulation of interleukin-23 production
I0034021biological_processresponse to silicon dioxide
I0034405biological_processresponse to fluid shear stress
I0038157biological_processgranulocyte-macrophage colony-stimulating factor signaling pathway
I0042045biological_processepithelial fluid transport
I0042127biological_processregulation of cell population proliferation
I0043011biological_processmyeloid dendritic cell differentiation
I0045187biological_processregulation of circadian sleep/wake cycle, sleep
I0045892biological_processnegative regulation of DNA-templated transcription
I0050793biological_processregulation of developmental process
I0070665biological_processpositive regulation of leukocyte proliferation
I0071222biological_processcellular response to lipopolysaccharide
I0071803biological_processpositive regulation of podosome assembly
I0097011biological_processcellular response to granulocyte macrophage colony-stimulating factor stimulus
I0097028biological_processdendritic cell differentiation
I0097696biological_processcell surface receptor signaling pathway via STAT
I2001240biological_processnegative regulation of extrinsic apoptotic signaling pathway in absence of ligand
J0001821biological_processhistamine secretion
J0001892biological_processembryonic placenta development
J0005125molecular_functioncytokine activity
J0005129molecular_functiongranulocyte macrophage colony-stimulating factor receptor binding
J0005515molecular_functionprotein binding
J0005576cellular_componentextracellular region
J0005615cellular_componentextracellular space
J0005886cellular_componentplasma membrane
J0006955biological_processimmune response
J0007165biological_processsignal transduction
J0007259biological_processcell surface receptor signaling pathway via JAK-STAT
J0008083molecular_functiongrowth factor activity
J0008283biological_processcell population proliferation
J0008284biological_processpositive regulation of cell population proliferation
J0009966biological_processregulation of signal transduction
J0010468biological_processregulation of gene expression
J0010628biological_processpositive regulation of gene expression
J0010744biological_processpositive regulation of macrophage derived foam cell differentiation
J0030099biological_processmyeloid cell differentiation
J0030223biological_processneutrophil differentiation
J0030224biological_processmonocyte differentiation
J0030225biological_processmacrophage differentiation
J0030335biological_processpositive regulation of cell migration
J0030526cellular_componentgranulocyte macrophage colony-stimulating factor receptor complex
J0032747biological_processpositive regulation of interleukin-23 production
J0034021biological_processresponse to silicon dioxide
J0034405biological_processresponse to fluid shear stress
J0038157biological_processgranulocyte-macrophage colony-stimulating factor signaling pathway
J0042045biological_processepithelial fluid transport
J0042127biological_processregulation of cell population proliferation
J0043011biological_processmyeloid dendritic cell differentiation
J0045187biological_processregulation of circadian sleep/wake cycle, sleep
J0045892biological_processnegative regulation of DNA-templated transcription
J0050793biological_processregulation of developmental process
J0070665biological_processpositive regulation of leukocyte proliferation
J0071222biological_processcellular response to lipopolysaccharide
J0071803biological_processpositive regulation of podosome assembly
J0097011biological_processcellular response to granulocyte macrophage colony-stimulating factor stimulus
J0097028biological_processdendritic cell differentiation
J0097696biological_processcell surface receptor signaling pathway via STAT
J2001240biological_processnegative regulation of extrinsic apoptotic signaling pathway in absence of ligand
K0001821biological_processhistamine secretion
K0001892biological_processembryonic placenta development
K0005125molecular_functioncytokine activity
K0005129molecular_functiongranulocyte macrophage colony-stimulating factor receptor binding
K0005515molecular_functionprotein binding
K0005576cellular_componentextracellular region
K0005615cellular_componentextracellular space
K0005886cellular_componentplasma membrane
K0006955biological_processimmune response
K0007165biological_processsignal transduction
K0007259biological_processcell surface receptor signaling pathway via JAK-STAT
K0008083molecular_functiongrowth factor activity
K0008283biological_processcell population proliferation
K0008284biological_processpositive regulation of cell population proliferation
K0009966biological_processregulation of signal transduction
K0010468biological_processregulation of gene expression
K0010628biological_processpositive regulation of gene expression
K0010744biological_processpositive regulation of macrophage derived foam cell differentiation
K0030099biological_processmyeloid cell differentiation
K0030223biological_processneutrophil differentiation
K0030224biological_processmonocyte differentiation
K0030225biological_processmacrophage differentiation
K0030335biological_processpositive regulation of cell migration
K0030526cellular_componentgranulocyte macrophage colony-stimulating factor receptor complex
K0032747biological_processpositive regulation of interleukin-23 production
K0034021biological_processresponse to silicon dioxide
K0034405biological_processresponse to fluid shear stress
K0038157biological_processgranulocyte-macrophage colony-stimulating factor signaling pathway
K0042045biological_processepithelial fluid transport
K0042127biological_processregulation of cell population proliferation
K0043011biological_processmyeloid dendritic cell differentiation
K0045187biological_processregulation of circadian sleep/wake cycle, sleep
K0045892biological_processnegative regulation of DNA-templated transcription
K0050793biological_processregulation of developmental process
K0070665biological_processpositive regulation of leukocyte proliferation
K0071222biological_processcellular response to lipopolysaccharide
K0071803biological_processpositive regulation of podosome assembly
K0097011biological_processcellular response to granulocyte macrophage colony-stimulating factor stimulus
K0097028biological_processdendritic cell differentiation
K0097696biological_processcell surface receptor signaling pathway via STAT
K2001240biological_processnegative regulation of extrinsic apoptotic signaling pathway in absence of ligand
Functional Information from PROSITE/UniProt
site_idPS00290
Number of Residues7
DetailsIG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YICNVNH
ChainResidueDetails
HTYR193-HIS199
LTYR193-HIS199

site_idPS00702
Number of Residues9
DetailsGM_CSF Granulocyte-macrophage colony-stimulating factor signature. CPPTpETsC
ChainResidueDetails
GCYS88-CYS96

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues12
DetailsCARBOHYD: O-linked (GalNAc...) serine => ECO:0000269|PubMed:1737041
ChainResidueDetails
GSER5
KSER5
KSER7
KSER9
GSER7
GSER9
JSER5
JSER7
JSER9
ISER5
ISER7
ISER9

site_idSWS_FT_FI2
Number of Residues4
DetailsCARBOHYD: O-linked (GalNAc...) threonine; partial => ECO:0000269|PubMed:1737041
ChainResidueDetails
GTHR10
JTHR10
ITHR10
KTHR10

site_idSWS_FT_FI3
Number of Residues8
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine
ChainResidueDetails
GASN27
GASN37
JASN27
JASN37
IASN27
IASN37
KASN27
KASN37

238268

PDB entries from 2025-07-02

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