6B1M
Disrupted hydrogen bond network impairs ATPase activity in an Hsc70 cysteine mutant
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | B, A | Heat shock protein family A (Hsp70) member 8 | polymer | 400 | 44134.8 | 2 | UniProt (P11142) Pfam (PF00012) In PDB | Homo Sapiens | |
2 | B, A | PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER | non-polymer | 506.2 | 2 | Chemie (ANP) | |||
3 | B, A | MAGNESIUM ION | non-polymer | 24.3 | 2 | Chemie (MG) | |||
4 | A | GLYCEROL | non-polymer | 92.1 | 2 | Chemie (GOL) | |||
5 | water | water | 18.0 | 854 | Chemie (HOH) |
Sequence modifications
B, A: 5 - 381 (UniProt: P11142)
PDB | External Database | Details |
---|---|---|
Met -22 | - | initiating methionine |
Gly -21 | - | expression tag |
Ser -20 | - | expression tag |
Ser -19 | - | expression tag |
His -18 | - | expression tag |
His -17 | - | expression tag |
His -16 | - | expression tag |
His -15 | - | expression tag |
His -14 | - | expression tag |
His -13 | - | expression tag |
Ser -12 | - | expression tag |
Ser -11 | - | expression tag |
Gly -10 | - | expression tag |
Leu -9 | - | expression tag |
Val -8 | - | expression tag |
Pro -7 | - | expression tag |
Arg -6 | - | expression tag |
Gly -5 | - | expression tag |
Ser -4 | - | expression tag |
His -3 | - | expression tag |
Met -2 | - | expression tag |
Ala -1 | - | expression tag |
Ser 0 | - | expression tag |
Trp 17 | Cys 17 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 2 |
Total formula weight | 88269.6 | |
Non-Polymers* | Number of molecules | 6 |
Total formula weight | 1245.2 | |
All* | Total formula weight | 89514.8 |