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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

6AZ1

Cryo-EM structure of the small subunit of Leishmania ribosome bound to paromomycin

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A
(A)		Ribosomal protein s1epolymer26430092.11UniProt (E9BRS2)Leishmania donovani
2B
(B)		ribosomal protein S2polymer24627564.71Pfam (PF00318)
UniProt (by SIFTS) (A4IDS4)		Leishmania donovani
3C
(C)		ribosomal protein S3polymer21924511.81UniProt (E9BQ25)Leishmania donovani
4D
(D)		ribosomal protein S4polymer19022184.91UniProt (E9BTJ0)
UniProt (by SIFTS) (A0A3S5H5Z2)		Leishmania donovani
5E
(E)		ribosomal protein S4epolymer27330711.11UniProt (E9BBI6)
UniProt (by SIFTS) (A0A3Q8I8K3)		Leishmania donovani
6F
(F)		ribosomal protein S5polymer26528803.21UniProt (E9BNF0)
UniProt (by SIFTS) (A0A3S7X558)		Leishmania donovani
7G
(G)		ribosomal protein S6epolymer24928341.21UniProt (by SIFTS) (O44012)Leishmania donovani
8H
(H)		ribosomal protein S7polymer19021311.61Pfam (PF00177)
UniProt (by SIFTS) (A0A381MCG8)		Leishmania donovani
9I
(I)		ribosomal protein S7epolymer20023867.31UniProt (E9B7A8)
UniProt (by SIFTS) (A0A3S7WNJ7)		Leishmania donovani
10J
(J)		ribosomal protein S8polymer13014719.31UniProt (E9BAV6)Leishmania donovani
11K
(K)		ribosomal protein S8epolymer22025038.31UniProt (E9BH78)
UniProt (by SIFTS) (A0A3Q8ID68)		Leishmania donovani
12L
(L)		ribosomal protein S9polymer14916718.61UniProt (E9BI96)Leishmania donovani
13M
(M)		ribosomal protein S10polymer11613049.11UniProt (by SIFTS) (E9BJI2)Leishmania donovani
14N
(N)		ribosomal protein S10epolymer15317432.91UniProt (E9BTG4)Leishmania donovani
15O
(O)		ribosomal protein S11polymer14415609.11UniProt (E9BMA8)
UniProt (by SIFTS) (A0A3S7X3Z7)		Leishmania donovani
16P
(P)		ribosomal protein S12polymer14315952.71UniProt (E9BFB6)Leishmania donovani
17Q
(Q)		ribosomal protein S12epolymer14115611.81UniProt (E9BBC0)
UniProt (by SIFTS) (A0A3S5H6N5)		Leishmania donovani
18R
(R)		ribosomal protein S13polymer15317443.41UniProt (E9BTF9)Leishmania donovani
19S
(S)		ribosomal protein S14polymer576696.91UniProt (E9BJV7)Leishmania donovani
20T
(T)		ribosomal protein S15polymer15117455.71UniProt (E9BPR7)
UniProt (by SIFTS) (A0A3S7X790)		Leishmania donovani
21U
(U)		ribosomal protein S17polymer17319985.41UniProt (by SIFTS) (Q9TXA6)Leishmania donovani
22V
(V)		ribosomal protein S17epolymer14316521.51UniProt (E9BJZ5)Leishmania donovani
23W
(W)		ribosomal protein S19polymer15217528.51UniProt (by SIFTS) (E9BFQ0)Leishmania donovani
24X
(X)		ribosomal protein S19epolymer17920188.61UniProt (E9BR60)Leishmania donovani
25Y
(Y)		ribosomal protein S21epolymer15916669.11UniProt (by SIFTS) (E9BAR6)Leishmania donovani
26Z
(Z)		ribosomal protein S24epolymer13715808.91UniProt (E9BU11)
UniProt (by SIFTS) (A0A3Q8IKW0)		Leishmania donovani
27AA
(a)		ribosomal protein S25epolymer12013071.41UniProt (E9BHM6)Leishmania donovani
28BA
(b)		ribosomal protein S26epolymer11212794.31UniProt (E9BK95)Leishmania donovani
29CA
(c)		ribosomal protein S27epolymer869819.51UniProt (E9BUA2)
UniProt (by SIFTS) (A0A3Q8ID11)		Leishmania donovani
30DA
(d)		ribosomal protein S28epolymer879763.21UniProt (E9BIH3)Leishmania donovani
31EA
(e)		ribosomal protein S30epolymer667394.91UniProt (E9BLG3)Leishmania donovani
32FA
(f)		ribosomal protein S31epolymer15217015.71UniProt (E9BTC5)
UniProt (by SIFTS) (A0A3S7XAC2)		Leishmania donovani
33GA
(g)		LACK1polymer31234459.51UniProt (Q9BIJ5)Leishmania donovani
34HA
(1)		ribosomal RNA 18Spolymer2203710287.41GenBank (322500086)Leishmania donovani
35IA
(2)		tRNA-Phepolymer7624599.71GenBank (1229082179)Escherichia coli
36JA
(3)		P-site tRNApolymer7724786.81GenBank (817573384)Escherichia coli
37KA
(4)		E-site tRNApolymer7624485.51GenBank (1229082179)Escherichia coli
38LA
(5)		mRNApolymer134085.51Leishmania donovani
39AB, BB, CB, DB, EB...
(1, C, D, S, 5)		MAGNESIUM IONnon-polymer24.324Chemie (MG)
PubChem (888)
40QA, RA, SA, TA, UA...
(1)		PAROMOMYCINnon-polymer615.66Chemie (PAR)
PubChem (16757804)
PubChem (16760604)
PubChem (17757254)
PubChem (20849281)
PubChem (71191297)
PubChem (23789070)
PubChem (24096964)
PubChem (24867526)
PubChem (24867858)
PubChem (25104843)
PubChem (44120093)
PubChem (44251565)
PubChem (71188564)
PubChem (53486370)
PubChem (165580)
PubChem (44186758)
PubChem (58160567)
PubChem (44663324)
PubChem (59361026)
PubChem (59800245)
PubChem (45358711)
PubChem (70793652)
PubChem (70793824)
PubChem (70795918)
PubChem (71068776)
PubChem (71072581)
PubChem (71072592)
PubChem (50989619)
PubChem (66932615)
PubChem (68032118)
PubChem (4689)
PubChem (14951)
PubChem (24176)
PubChem (70878598)
PubChem (71751432)
PubChem (73707499)
PubChem (3040200)
PubChem (91151908)
PubChem (91867972)
PubChem (91972181)
PubChem (94469268)
PubChem (98048759)
PubChem (98048761)
PubChem (5702262)
PubChem (121292209)
PubChem (6603975)
PubChem (6604293)
PubChem (122537356)
PubChem (6710686)
PubChem (124226135)
PubChem (124464537)
PubChem (9809147)
PubChem (125040357)
PubChem (125040359)
PubChem (125121197)
PubChem (94469269)
PubChem (94469270)
PubChem (94469271)
PubChem (129009945)
PubChem (131841783)
PubChem (132275078)
PubChem (6602492)
PubChem (6713982)
PubChem (98048758)
PubChem (98048760)
PubChem (101739930)
PubChem (118213779)
PubChem (118705495)
PubChem (9961808)
PubChem (122691713)
PubChem (12313981)
PubChem (124226132)
PubChem (124226133)
PubChem (124226134)
PubChem (124464538)
PubChem (124761786)
PubChem (124761787)
PubChem (124761788)
PubChem (124761789)
PubChem (152952600)
PubChem (125040358)
PubChem (125040360)
PubChem (125121198)
PubChem (162873319)
PubChem (129014632)
PubChem (129014634)
PubChem (129014635)
PubChem (129313238)
PubChem (134771120)
PubChem (137404838)
PubChem (161153506)
PubChem (163199098)
PubChem (164850471)
PubChem (172091638)
PubChem (173719997)
41AC, BC, CC, DC, EC...
(R, S, T, X, Y...)		waterwater18.0262Chemie (HOH)
Sequence modifications
A: 0 - 263 (UniProt: E9BRS2)
PDBExternal DatabaseDetails
Ser 15Gly 16conflict
F: 1 - 265 (UniProt: E9BNF0)
PDBExternal DatabaseDetails
Thr 4Ala 4conflict
Gln 8-insertion
Ala 10Asn 9conflict
Ala 12Gly 11conflict
Ala 13Val 12conflict
Asp 14Glu 13conflict
Val 15Ala 14conflict
P: 1 - 143 (UniProt: E9BFB6)
PDBExternal DatabaseDetails
Arg 18Cys 18conflict
Ala 34Ser 34conflict
Lys 36Arg 36conflict
Ser 127Asn 127conflict
f: 1 - 152 (UniProt: E9BTC5)
PDBExternal DatabaseDetails
Ile 5Val 5conflict
1: 1 - 2203 (GenBank: 322500086)
PDBExternal DatabaseDetails
M1y 1539U 1020612conflict
C4j 1543U 1020608conflict
2: 4 - 76 (GenBank: 1229082179)
PDBExternal DatabaseDetails
G 1-expression tag
C 2-expression tag
G 3-expression tag
C 70G 899645conflict
4: 4 - 76 (GenBank: 1229082179)
PDBExternal DatabaseDetails
G 1-expression tag
C 2-expression tag
G 3-expression tag
C 70G 899645conflict
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains38
Total formula weight1412381.0
Non-Polymers*Number of molecules30
Total formula weight4277.1
All*Total formula weight1416658.1
*Water molecules are not included.

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PDB entries from 2026-05-06

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