Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

6AZ1

Cryo-EM structure of the small subunit of Leishmania ribosome bound to paromomycin

Functional Information from GO Data

Chain	GOid	namespace	contents
a	0003735	molecular_function	structural constituent of ribosome
a	0005840	cellular_component	ribosome
a	0022627	cellular_component	cytosolic small ribosomal subunit
a	1990904	cellular_component	ribonucleoprotein complex
A	0003735	molecular_function	structural constituent of ribosome
A	0005737	cellular_component	cytoplasm
A	0005840	cellular_component	ribosome
A	0006412	biological_process	translation
A	0022627	cellular_component	cytosolic small ribosomal subunit
A	1990904	cellular_component	ribonucleoprotein complex
b	0003729	molecular_function	mRNA binding
b	0003735	molecular_function	structural constituent of ribosome
b	0005840	cellular_component	ribosome
b	0006412	biological_process	translation
b	0022627	cellular_component	cytosolic small ribosomal subunit
b	1990904	cellular_component	ribonucleoprotein complex
B	0000028	biological_process	ribosomal small subunit assembly
B	0003735	molecular_function	structural constituent of ribosome
B	0005737	cellular_component	cytoplasm
B	0005840	cellular_component	ribosome
B	0006412	biological_process	translation
B	0015935	cellular_component	small ribosomal subunit
B	0022627	cellular_component	cytosolic small ribosomal subunit
B	1990904	cellular_component	ribonucleoprotein complex
c	0003735	molecular_function	structural constituent of ribosome
c	0005840	cellular_component	ribosome
c	0006412	biological_process	translation
C	0003723	molecular_function	RNA binding
C	0003735	molecular_function	structural constituent of ribosome
C	0006412	biological_process	translation
C	0015935	cellular_component	small ribosomal subunit
d	0003735	molecular_function	structural constituent of ribosome
d	0005840	cellular_component	ribosome
d	0006412	biological_process	translation
D	0003723	molecular_function	RNA binding
D	0003735	molecular_function	structural constituent of ribosome
D	0005840	cellular_component	ribosome
D	0006412	biological_process	translation
D	0015935	cellular_component	small ribosomal subunit
D	0019843	molecular_function	rRNA binding
D	0022627	cellular_component	cytosolic small ribosomal subunit
D	0042274	biological_process	ribosomal small subunit biogenesis
D	0043226	cellular_component	organelle
D	1990904	cellular_component	ribonucleoprotein complex
e	0003735	molecular_function	structural constituent of ribosome
e	0005829	cellular_component	cytosol
e	0005840	cellular_component	ribosome
e	0006412	biological_process	translation
e	1990904	cellular_component	ribonucleoprotein complex
E	0003723	molecular_function	RNA binding
E	0003735	molecular_function	structural constituent of ribosome
E	0005840	cellular_component	ribosome
E	0006412	biological_process	translation
E	0019843	molecular_function	rRNA binding
E	1990904	cellular_component	ribonucleoprotein complex
f	0003735	molecular_function	structural constituent of ribosome
f	0005634	cellular_component	nucleus
f	0005737	cellular_component	cytoplasm
f	0005840	cellular_component	ribosome
f	0006412	biological_process	translation
f	0016567	biological_process	protein ubiquitination
f	0019941	biological_process	modification-dependent protein catabolic process
f	0031386	molecular_function	protein tag activity
f	0031625	molecular_function	ubiquitin protein ligase binding
f	1990904	cellular_component	ribonucleoprotein complex
F	0003723	molecular_function	RNA binding
F	0003735	molecular_function	structural constituent of ribosome
F	0005840	cellular_component	ribosome
F	0006412	biological_process	translation
F	0015935	cellular_component	small ribosomal subunit
F	0022627	cellular_component	cytosolic small ribosomal subunit
F	1990904	cellular_component	ribonucleoprotein complex
g	0005840	cellular_component	ribosome
g	0006417	biological_process	regulation of translation
g	0043022	molecular_function	ribosome binding
g	0045182	molecular_function	translation regulator activity
g	1990904	cellular_component	ribonucleoprotein complex
G	0003735	molecular_function	structural constituent of ribosome
G	0005634	cellular_component	nucleus
G	0005730	cellular_component	nucleolus
G	0005737	cellular_component	cytoplasm
G	0005840	cellular_component	ribosome
G	0006412	biological_process	translation
G	0032040	cellular_component	small-subunit processome
G	0042274	biological_process	ribosomal small subunit biogenesis
G	1990904	cellular_component	ribonucleoprotein complex
H	0003735	molecular_function	structural constituent of ribosome
H	0005840	cellular_component	ribosome
H	0006412	biological_process	translation
H	0015935	cellular_component	small ribosomal subunit
H	1990904	cellular_component	ribonucleoprotein complex
I	0003735	molecular_function	structural constituent of ribosome
I	0005840	cellular_component	ribosome
I	0006412	biological_process	translation
I	1990904	cellular_component	ribonucleoprotein complex
J	0003735	molecular_function	structural constituent of ribosome
J	0005840	cellular_component	ribosome
J	0006412	biological_process	translation
J	1990904	cellular_component	ribonucleoprotein complex
K	0003735	molecular_function	structural constituent of ribosome
K	0005840	cellular_component	ribosome
K	0006412	biological_process	translation
K	1990904	cellular_component	ribonucleoprotein complex
L	0003735	molecular_function	structural constituent of ribosome
L	0005840	cellular_component	ribosome
L	0006412	biological_process	translation
L	1990904	cellular_component	ribonucleoprotein complex
M	0003735	molecular_function	structural constituent of ribosome
M	0005840	cellular_component	ribosome
M	0006412	biological_process	translation
M	0015935	cellular_component	small ribosomal subunit
M	1990904	cellular_component	ribonucleoprotein complex
N	0005737	cellular_component	cytoplasm
N	0005840	cellular_component	ribosome
O	0000028	biological_process	ribosomal small subunit assembly
O	0003735	molecular_function	structural constituent of ribosome
O	0005840	cellular_component	ribosome
O	0006412	biological_process	translation
O	0022627	cellular_component	cytosolic small ribosomal subunit
O	1990904	cellular_component	ribonucleoprotein complex
P	0003735	molecular_function	structural constituent of ribosome
P	0005840	cellular_component	ribosome
P	0006412	biological_process	translation
P	0015935	cellular_component	small ribosomal subunit
P	0022627	cellular_component	cytosolic small ribosomal subunit
P	1990904	cellular_component	ribonucleoprotein complex
Q	0003735	molecular_function	structural constituent of ribosome
Q	0005840	cellular_component	ribosome
Q	0006412	biological_process	translation
Q	1990904	cellular_component	ribonucleoprotein complex
R	0003676	molecular_function	nucleic acid binding
R	0003723	molecular_function	RNA binding
R	0003735	molecular_function	structural constituent of ribosome
R	0005829	cellular_component	cytosol
R	0005840	cellular_component	ribosome
R	0006412	biological_process	translation
R	0015935	cellular_component	small ribosomal subunit
R	1990904	cellular_component	ribonucleoprotein complex
S	0003735	molecular_function	structural constituent of ribosome
S	0005840	cellular_component	ribosome
S	0006412	biological_process	translation
S	0008270	molecular_function	zinc ion binding
S	1990904	cellular_component	ribonucleoprotein complex
T	0003735	molecular_function	structural constituent of ribosome
T	0005840	cellular_component	ribosome
T	0006412	biological_process	translation
T	1990904	cellular_component	ribonucleoprotein complex
U	0003735	molecular_function	structural constituent of ribosome
U	0005840	cellular_component	ribosome
U	0006412	biological_process	translation
U	1990904	cellular_component	ribonucleoprotein complex
V	0003735	molecular_function	structural constituent of ribosome
V	0005840	cellular_component	ribosome
V	0006412	biological_process	translation
V	1990904	cellular_component	ribonucleoprotein complex
W	0003723	molecular_function	RNA binding
W	0003735	molecular_function	structural constituent of ribosome
W	0005840	cellular_component	ribosome
W	0006412	biological_process	translation
W	0015935	cellular_component	small ribosomal subunit
W	1990904	cellular_component	ribonucleoprotein complex
X	0000028	biological_process	ribosomal small subunit assembly
X	0003723	molecular_function	RNA binding
X	0003735	molecular_function	structural constituent of ribosome
X	0005840	cellular_component	ribosome
X	0006412	biological_process	translation
X	0022627	cellular_component	cytosolic small ribosomal subunit
X	1990904	cellular_component	ribonucleoprotein complex
Y	0003735	molecular_function	structural constituent of ribosome
Y	0005840	cellular_component	ribosome
Y	0006412	biological_process	translation
Z	0003735	molecular_function	structural constituent of ribosome
Z	0005840	cellular_component	ribosome
Z	0006412	biological_process	translation
Z	1990904	cellular_component	ribonucleoprotein complex

Functional Information from PDB Data

site_id	AC1
Number of Residues	1
Details	binding site for residue MG C 301

Chain	Residue
C	ARG66

site_id	AC2
Number of Residues	1
Details	binding site for residue MG S 101

Chain	Residue
S	GLU36

site_id	AC3
Number of Residues	10
Details	binding site for residue PAR 1 2302

Chain	Residue
1	A2159
1	G2160
1	U2161
1	G2062
1	C2064
1	G2065
1	C2155
1	A2156
1	A2157
1	A2158

site_id	AC4
Number of Residues	8
Details	binding site for residue PAR 1 2303

Chain	Residue
1	A1290
1	U1291
1	U1292
1	G1293
1	G1294
1	U1420
1	C1421
1	U1422

site_id	AC5
Number of Residues	12
Details	binding site for residue PAR 1 2304

Chain	Residue
1	A1509
1	C1510
1	C1511
1	U1637
1	U1638
1	G1639
1	G1664
1	U1815
1	G1818
1	G1819
1	U2002
L	ARG141

site_id	AC6
Number of Residues	10
Details	binding site for residue PAR 1 2305

Chain	Residue
1	A22
1	G23
1	U24
1	A26
1	G646
1	U647
1	A648
1	U649
1	U651
P	GLY106

site_id	AC7
Number of Residues	9
Details	binding site for residue PAR 1 2306

Chain	Residue
1	U2067
1	G2068
1	U2069
1	U2070
1	A2149
1	G2150
1	A2152
1	A2153
1	G2154

site_id	AC8
Number of Residues	7
Details	binding site for residue PAR 1 2307

Chain	Residue
1	U365
1	G366
1	A2085
1	A2086
1	C2132
1	G2133
1	A2134

site_id	AC9
Number of Residues	2
Details	binding site for residue MG 1 2308

Chain	Residue
1	A783
1	C835

site_id	AD1
Number of Residues	1
Details	binding site for residue MG 1 2309

Chain	Residue
1	A629

site_id	AD2
Number of Residues	1
Details	binding site for residue MG 1 2310

Chain	Residue
1	G1189

site_id	AD3
Number of Residues	1
Details	binding site for residue MG 1 2311

Chain	Residue
1	A1109

site_id	AD4
Number of Residues	1
Details	binding site for residue MG 1 2312

Chain	Residue
1	G432

site_id	AD5
Number of Residues	1
Details	binding site for residue MG 1 2315

Chain	Residue
1	G1531

Functional Information from PROSITE/UniProt

site_id	PS00053
Number of Residues	18
Details	RIBOSOMAL_S8 Ribosomal protein S8 signature. GfvVLTTSlGIMdheeAR

Chain	Residue	Details
J	GLY100-ARG117

site_id	PS00054
Number of Residues	23
Details	RIBOSOMAL_S11 Ribosomal protein S11 signature. LrALarA.GMkIgrieDvTPiPTD

Chain	Residue	Details
O	LEU109-ASP131

site_id	PS00055
Number of Residues	8
Details	RIBOSOMAL_S12 Ribosomal protein S12 signature. KqPNSAiR

Chain	Residue	Details
P	LYS60-ARG67

site_id	PS00056
Number of Residues	13
Details	RIBOSOMAL_S17 Ribosomal protein S17 signature. GDeVvVgQcRPLS

Chain	Residue	Details
U	GLY135-SER147

site_id	PS00107
Number of Residues	22
Details	PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. IGMGKGARCCvIcsnqka............LIRK

Chain	Residue	Details
S	ILE13-LYS34

site_id	PS00216
Number of Residues	18
Details	SUGAR_TRANSPORT_1 Sugar transport proteins signature 1. MIYPSDVVGRRwrcrtdG

Chain	Residue	Details
I	MET132-GLY149

site_id	PS00323
Number of Residues	25
Details	RIBOSOMAL_S19 Ribosomal protein S19 signature. NGHqfnaveIkgemIGhyLGEFsmS

Chain	Residue	Details
W	ASN105-SER129

site_id	PS00360
Number of Residues	19
Details	RIBOSOMAL_S9 Ribosomal protein S9 signature. GGGqvSQayAarqAiAKGL

Chain	Residue	Details
L	GLY77-LEU95

site_id	PS00362
Number of Residues	31
Details	RIBOSOMAL_S15 Ribosomal protein S15 signature. MrkHLerhTtDrdTkyrLilVesrihrLarY

Chain	Residue	Details
T	MET98-TYR128

site_id	PS00529
Number of Residues	23
Details	RIBOSOMAL_S24E Ribosomal protein S24e signature. FGggKTtGFGlIYDDlaslkrfE

Chain	Residue	Details
Z	PHE71-GLU93

site_id	PS00578
Number of Residues	12
Details	RIBOSOMAL_S6E Ribosomal protein S6e signature. LRGGsDkdGfPM

Chain	Residue	Details
G	LEU53-MET64

site_id	PS00585
Number of Residues	33
Details	RIBOSOMAL_S5 Ribosomal protein S5 signature. GQrtrFkAfnVVGDcd.GhIGiGarvgk.EVsl.AI

Chain	Residue	Details
F	GLY105-ILE137

site_id	PS00632
Number of Residues	25
Details	RIBOSOMAL_S4 Ribosomal protein S4 signature. LErRLqtiVFKaglAkSvhhARvLI

Chain	Residue	Details
D	LEU104-ILE128

site_id	PS00646
Number of Residues	14
Details	RIBOSOMAL_S13_1 Ribosomal protein S13 signature. RGvRHayGlrVRGQ

Chain	Residue	Details
R	ARG122-GLN135

site_id	PS00678
Number of Residues	15
Details	WD_REPEATS_1 Trp-Asp (WD) repeats signature. ALTAswDrSIRMWDL

Chain	Residue	Details
g	ALA80-LEU94
g	ILE122-VAL136
g	VAL167-VAL181
g	CYS209-LEU223

site_id	PS00961
Number of Residues	9
Details	RIBOSOMAL_S28E Ribosomal protein S28e signature. ETEREARrL

Chain	Residue	Details
d	GLU77-LEU85

site_id	PS00963
Number of Residues	25
Details	RIBOSOMAL_S2_2 Ribosomal protein S2 signature 2. PrvLVVtDprtDhqaIrEaslvNIP

Chain	Residue	Details
B	PRO122-PRO146

site_id	PS01193
Number of Residues	20
Details	RIBOSOMAL_S8E Ribosomal protein S8e signature. RkiTGGktkih.RkRmKaELG

Chain	Residue	Details
K	ARG11-GLY30

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)