6AYN

Structure of cetuximab with aminoheptanoic acid-linked N-(3-aminopropyl)-L-arginine meditope variant

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, C (A, C)	Cetuximab Fab light chain	polymer	213	23287.7	2	UniProt (P01834) Pfam (PF07654)	Mus musculus (Mouse)
2	B, D (B, D)	Cetuximab Fab heavy chain	polymer	221	23725.5	2	UniProt (S6B291) Pfam (PF07686) Pfam (PF07654)	Mus musculus (Mouse)
3	E, F (E, F)	Cyclic meditope	polymer	11	1449.7	2		synthetic construct
4	G, H, I, J, K... (A, B, C, D, E...)	water	water		18.0	458	Chemie (HOH)

Sequence modifications

A, C: 1 - 107 (PDB: 6AYN)
A, C: 108 - 213 (UniProt: P01834)

PDB	External Database	Details
Ala 213	Glu 106	conflict

B, D: 1 - 107 (PDB: 6AYN)
B, D: 108 - 221 (UniProt: S6B291)

PDB	External Database	Details
Ala 119	Ser 136	conflict

Contents of the asymmetric unit

Polymers	Number of chains	6
	Total formula weight	96925.9
All*	Total formula weight	96925.9

*Water molecules are not included.