6AU6
Crystal structure of GDP-bound human GNAS R201C mutant
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Guanine nucleotide-binding protein G(s) subunit alpha isoforms short | polymer | 377 | 44020.8 | 1 | UniProt (P63092) Pfam (PF00503) | Homo sapiens (Human) | Adenylate cyclase-stimulating G alpha protein |
| 2 | B (A) | GUANOSINE-5'-DIPHOSPHATE | non-polymer | 443.2 | 1 | Chemie (GDP) | |||
| 3 | C (A) | MAGNESIUM ION | non-polymer | 24.3 | 1 | Chemie (MG) | |||
| 4 | D (A) | CHLORIDE ION | non-polymer | 35.5 | 1 | Chemie (CL) | |||
| 5 | E, F (A) | GLYCEROL | non-polymer | 92.1 | 2 | Chemie (GOL) | |||
| 6 | G (A) | water | water | 18.0 | 249 | Chemie (HOH) |
Sequence modifications
A: 7 - 394 (UniProt: P63092)
| PDB | External Database | Details |
|---|---|---|
| Ala 4 | - | expression tag |
| His 5 | - | expression tag |
| Met 6 | - | expression tag |
| Cys 201 | Arg 187 | engineered mutation |
| Ser 237 | Cys 223 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 44020.8 | |
| Non-Polymers* | Number of molecules | 5 |
| Total formula weight | 687.1 | |
| All* | Total formula weight | 44707.9 |
