6AOD

FXIa antibody complex

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	FXIa Antibody FAB Light Chain	polymer	214	23270.9	1		Homo sapiens
2	B	FXIa Antibody FAB Heavy Chain	polymer	229	24666.6	1		Homo sapiens
3	C	Coagulation factor XI	polymer	245	27874.6	1	UniProt (P03951) Pfam (PF00089) In PDB	Homo sapiens (Human)	FXI,Plasma thromboplastin antecedent,PTA
4	A, B	SULFATE ION	non-polymer		96.1	4	Chemie (SO4)
5	A, B, C	GLYCEROL	non-polymer		92.1	9	Chemie (GOL)
6	B, C	COBALT (II) ION	non-polymer		58.9	3	Chemie (CO)
7	B, C	PHOSPHATE ION	non-polymer		95.0	5	Chemie (PO4)
8		water	water		18.0	560	Chemie (HOH)

Sequence modifications

C: 370 - 606 (UniProt: P03951)

PDB	External Database	Details
Gln 432	Asn 450	engineered mutation
Gln 473	Asn 491	engineered mutation
Ser 482	Cys 500	engineered mutation
Ala 557	Ser 575	engineered mutation
His 607	-	expression tag
His 608	-	expression tag
His 609	-	expression tag
His 610	-	expression tag
His 611	-	expression tag
His 612	-	expression tag
His 613	-	expression tag
His 614	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	3
	Total formula weight	75812.1
Non-Polymers*	Number of molecules	21
	Total formula weight	1864.8
All*	Total formula weight	77676.8

*Water molecules are not included.