6AOD

FXIa antibody complex

Functional Information from GO Data

Chain	GOid	namespace	contents
C	0004252	molecular_function	serine-type endopeptidase activity
C	0006508	biological_process	proteolysis

Functional Information from PDB Data

site_id	AC1
Number of Residues	9
Details	binding site for residue SO4 A 301

Chain	Residue
A	GLY34
A	TYR36
A	ARG46
A	TYR49
A	LEU89
A	HIS91
A	HOH421
B	LEU99
C	ARG507

---

site_id	AC2
Number of Residues	6
Details	binding site for residue GOL A 302

Chain	Residue
A	ASP92
A	ILE93
A	TYR94
A	ALA95
A	HOH402
C	ARG395

---

site_id	AC3
Number of Residues	7
Details	binding site for residue GOL A 303

Chain	Residue
A	ARG24
A	GLN160
A	THR180
A	HOH405
A	HOH483
B	GLN175
B	SER176

---

site_id	AC4
Number of Residues	6
Details	binding site for residue GOL A 304

Chain	Residue
A	SER121
A	ASP122
A	GLU123
A	HOH404
B	PRO127
B	LYS213

---

site_id	AC5
Number of Residues	1
Details	binding site for residue CO B 301

Chain	Residue
B	LYS205

---

site_id	AC6
Number of Residues	1
Details	binding site for residue CO B 302

Chain	Residue
B	GLY8

---

site_id	AC7
Number of Residues	2
Details	binding site for residue SO4 B 303

Chain	Residue
B	ARG85
B	ARG87

---

site_id	AC8
Number of Residues	5
Details	binding site for residue SO4 B 304

Chain	Residue
B	ARG98
B	PHE103
B	ARG104
B	TYR106
B	HOH402

---

site_id	AC9
Number of Residues	8
Details	binding site for residue SO4 B 305

Chain	Residue
B	TYR33
B	HIS35
B	LEU99
B	ALA100
B	HOH401
B	HOH406
B	HOH520
C	ARG507

---

site_id	AD1
Number of Residues	3
Details	binding site for residue PO4 B 306

Chain	Residue
B	TYR27
B	THR28
B	TYR32

---

site_id	AD2
Number of Residues	4
Details	binding site for residue GOL B 307

Chain	Residue
B	TYR60
B	GLN65
B	HOH443
B	HOH483

---

site_id	AD3
Number of Residues	1
Details	binding site for residue CO C 701

Chain	Residue
C	TYR474

---

site_id	AD4
Number of Residues	4
Details	binding site for residue PO4 C 702

Chain	Residue
C	ASP439
C	THR440
C	SER441
C	HOH904

---

site_id	AD5
Number of Residues	2
Details	binding site for residue PO4 C 703

Chain	Residue
C	THR393
C	GLN394

---

site_id	AD6
Number of Residues	6
Details	binding site for residue PO4 C 704

Chain	Residue
C	LYS518
C	TYR545
C	LYS550
C	HOH897
C	HOH898
C	HOH901

---

site_id	AD7
Number of Residues	2
Details	binding site for residue PO4 C 705

Chain	Residue
C	THR537
C	HIS538

---

site_id	AD8
Number of Residues	6
Details	binding site for residue GOL C 706

Chain	Residue
C	GLN432
C	ASN512
C	THR513
C	HOH851
C	HOH860
C	HOH873

---

site_id	AD9
Number of Residues	8
Details	binding site for residue GOL C 707

Chain	Residue
C	VAL377
C	GLY379
C	GLU380
C	TRP381
C	ILE430
C	SER477
C	LEU514
C	HOH845

---

site_id	AE1
Number of Residues	4
Details	binding site for residue GOL C 708

Chain	Residue
C	PHE443
C	GLN473
C	GLN478
C	VAL568

---

site_id	AE2
Number of Residues	6
Details	binding site for residue GOL C 709

Chain	Residue
B	VAL11
B	LYS13
B	SER119
B	THR120
B	SER191
C	SER420

---

site_id	AE3
Number of Residues	5
Details	binding site for residue GOL C 710

Chain	Residue
C	LYS505
C	LEU506
C	ARG507
C	HOH802
C	HOH803

---

Functional Information from PROSITE/UniProt

site_id	PS00134
Number of Residues	6
Details	TRYPSIN_HIS Serine proteases, trypsin family, histidine active site. LTAAHC

Chain	Residue	Details
C	LEU409-CYS414

---

site_id	PS00290
Number of Residues	7
Details	IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YACEVTH

Chain	Residue	Details
A	TYR192-HIS198
B	TYR198-HIS204

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	235
Details	Domain: {"description":"Peptidase S1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00274","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	3
Details	Active site: {"description":"Charge relay system"}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	3
Details	Binding site: {}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	1
Details	Glycosylation: {"description":"N-linked (GlcNAc...) (complex) asparagine","evidences":[{"source":"PubMed","id":"16335952","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19159218","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25092234","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	1
Details	Glycosylation: {"description":"N-linked (GlcNAc...) (complex) asparagine","evidences":[{"source":"PubMed","id":"16335952","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19159218","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"1998667","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25092234","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---