6A96
Cryo-EM structure of the human alpha5beta3 GABAA receptor in complex with GABA and Nb25
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | K, L, O | Nb25 | polymer | 125 | 13673.0 | 3 | Lama glama | ||
2 | B, E, C, D | Gamma-aminobutyric acid receptor subunit beta-3,Gamma-aminobutyric acid receptor subunit beta-3 | polymer | 366 | 42052.7 | 4 | UniProt (P28472) Pfam (PF02931) Pfam (PF02932) In PDB | Homo sapiens (Human) | GABA(A) receptor subunit beta-3,GABA(A) receptor subunit beta-3 |
3 | A | Gamma-aminobutyric acid receptor subunit alpha-5,Gamma-aminobutyric acid receptor subunit alpha-5 | polymer | 392 | 44456.1 | 1 | UniProt (P31644) Pfam (PF02931) Pfam (PF02932) In PDB | Homo sapiens (Human) | GABA(A) receptor subunit alpha-5,GABA(A) receptor subunit alpha-5 |
4 | F, J, N, Q | alpha-D-mannopyranose-(1-3)-alpha-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 1073.0 | 4 | In PDB GlyTouCan (G09724ZC) | |||
5 | G, M, P, R | beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 586.5 | 4 | In PDB GlyTouCan (G15407YE) | |||
6 | H | alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 910.8 | 1 | In PDB GlyTouCan (G22768VO) | |||
7 | I | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 1 | In PDB GlyTouCan (G42666HT) | |||
8 | B | GAMMA-AMINO-BUTANOIC ACID | non-polymer | 103.1 | 1 | Chemie (ABU) |
Sequence modifications
B, E, C, D: -24 - 307 (UniProt: P28472)
B, E, C, D: 422 - 448 (UniProt: P28472)
A: -30 - 315 (UniProt: P31644)
A: 393 - 431 (UniProt: P31644)
B, E, C, D: 422 - 448 (UniProt: P28472)
PDB | External Database | Details |
---|---|---|
Ser 308 | - | linker |
Gln 309 | - | linker |
Pro 310 | - | linker |
Ala 311 | - | linker |
Arg 312 | - | linker |
Ala 313 | - | linker |
Ala 314 | - | linker |
A: 393 - 431 (UniProt: P31644)
PDB | External Database | Details |
---|---|---|
Ser 316 | - | linker |
Gln 317 | - | linker |
Pro 318 | - | linker |
Ala 319 | - | linker |
Arg 320 | - | linker |
Ala 321 | - | linker |
Ala 322 | - | linker |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 8 |
Total formula weight | 253686.0 | |
Branched | Number of molecules | 10 |
Total formula weight | 7973.2 | |
Non-Polymers* | Number of molecules | 1 |
Total formula weight | 103.1 | |
All* | Total formula weight | 261762.4 |