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6A96

Cryo-EM structure of the human alpha5beta3 GABAA receptor in complex with GABA and Nb25

Functional Information from GO Data
ChainGOidnamespacecontents
A0004888molecular_functiontransmembrane signaling receptor activity
A0004890molecular_functionGABA-A receptor activity
A0005216molecular_functionmonoatomic ion channel activity
A0005230molecular_functionextracellular ligand-gated monoatomic ion channel activity
A0006811biological_processmonoatomic ion transport
A0006821biological_processchloride transport
A0007214biological_processgamma-aminobutyric acid signaling pathway
A0016020cellular_componentmembrane
A0034220biological_processmonoatomic ion transmembrane transport
B0004888molecular_functiontransmembrane signaling receptor activity
B0004890molecular_functionGABA-A receptor activity
B0005216molecular_functionmonoatomic ion channel activity
B0005230molecular_functionextracellular ligand-gated monoatomic ion channel activity
B0006811biological_processmonoatomic ion transport
B0016020cellular_componentmembrane
B0034220biological_processmonoatomic ion transmembrane transport
C0004888molecular_functiontransmembrane signaling receptor activity
C0004890molecular_functionGABA-A receptor activity
C0005216molecular_functionmonoatomic ion channel activity
C0005230molecular_functionextracellular ligand-gated monoatomic ion channel activity
C0006811biological_processmonoatomic ion transport
C0016020cellular_componentmembrane
C0034220biological_processmonoatomic ion transmembrane transport
D0004888molecular_functiontransmembrane signaling receptor activity
D0004890molecular_functionGABA-A receptor activity
D0005216molecular_functionmonoatomic ion channel activity
D0005230molecular_functionextracellular ligand-gated monoatomic ion channel activity
D0006811biological_processmonoatomic ion transport
D0016020cellular_componentmembrane
D0034220biological_processmonoatomic ion transmembrane transport
E0004888molecular_functiontransmembrane signaling receptor activity
E0004890molecular_functionGABA-A receptor activity
E0005216molecular_functionmonoatomic ion channel activity
E0005230molecular_functionextracellular ligand-gated monoatomic ion channel activity
E0006811biological_processmonoatomic ion transport
E0016020cellular_componentmembrane
E0034220biological_processmonoatomic ion transmembrane transport
Functional Information from PROSITE/UniProt
site_idPS00236
Number of Residues15
DetailsNEUROTR_ION_CHANNEL Neurotransmitter-gated ion-channels signature. CmMdLrrYPlDeqnC
ChainResidueDetails
BCYS136-CYS150
ACYS142-CYS156

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues228
DetailsTOPO_DOM: Extracellular => ECO:0000255
ChainResidueDetails
AGLN1-PHE229
BLEU268-LYS279
EGLN1-PHE221
ELEU268-LYS279
CGLN1-PHE221
CLEU268-LYS279
DGLN1-PHE221
DLEU268-LYS279

site_idSWS_FT_FI2
Number of Residues82
DetailsTRANSMEM: Helical => ECO:0000269|PubMed:30140029, ECO:0007744|PDB:6A96
ChainResidueDetails
AVAL230-LEU250
CSER247-HIS267
CALA280-ASN303
CILE423-TYR445
DILE222-ILE242
DSER247-HIS267
DALA280-ASN303
DILE423-TYR445
APRO256-ARG277
AALA288-THR309
AMET397-TYR417
EILE222-ILE242
ESER247-HIS267
EALA280-ASN303
EILE423-TYR445
CILE222-ILE242

site_idSWS_FT_FI3
Number of Residues4
DetailsTOPO_DOM: Cytoplasmic => ECO:0000305
ChainResidueDetails
AASN251-VAL255
EASN243-ALA246
CASN243-ALA246
DASN243-ALA246

site_idSWS_FT_FI4
Number of Residues22
DetailsTOPO_DOM: Extracellular => ECO:0000305
ChainResidueDetails
AASN278-THR287
ALEU418-LYS431
CTYR446-ASN448
DTYR446-ASN448

site_idSWS_FT_FI5
Number of Residues1
DetailsBINDING: BINDING => ECO:0000269|PubMed:30140029, ECO:0007744|PDB:6A96
ChainResidueDetails
AARG70
BPHE200
EASP95
EPHE200
CASP95
CPHE200
DASP95
DPHE200

site_idSWS_FT_FI6
Number of Residues1
DetailsBINDING: BINDING => ECO:0000250|UniProtKB:P62813
ChainResidueDetails
ATHR133
DTYR97
DSER156
DTHR202
BSER156
BTHR202
ETYR97
ESER156
ETHR202
CTYR97
CSER156
CTHR202

site_idSWS_FT_FI7
Number of Residues2
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255
ChainResidueDetails
AASN14
AASN176
CGLU155
DGLU155

site_idSWS_FT_FI8
Number of Residues2
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:30140029, ECO:0007744|PDB:6A96
ChainResidueDetails
AASN114
AASN205
CTYR157
DTYR157

site_idSWS_FT_FI9
Number of Residues4
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:24909990, ECO:0000269|PubMed:35355020, ECO:0007744|PDB:7QN7
ChainResidueDetails
BASN8
EASN8
CASN8
DASN8

site_idSWS_FT_FI10
Number of Residues4
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:24909990, ECO:0000269|PubMed:30602789, ECO:0000269|PubMed:35355020, ECO:0007744|PDB:6I53, ECO:0007744|PDB:7QN7
ChainResidueDetails
BASN80
EASN80
CASN80
DASN80

site_idSWS_FT_FI11
Number of Residues4
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:24909990, ECO:0000269|PubMed:30140029, ECO:0000269|PubMed:30602789, ECO:0000269|PubMed:35355020, ECO:0007744|PDB:6A96, ECO:0007744|PDB:6I53, ECO:0007744|PDB:7QN7
ChainResidueDetails
BASN149
EASN149
CASN149
DASN149

227561

PDB entries from 2024-11-20

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