6A70

Structure of the human PKD1/PKD2 complex

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, C, D (A, F, G)	Polycystin-2	polymer	577	66623.4	3	UniProt (Q13563) Pfam (PF20519) Pfam (PF00520) Pfam (PF08016)	Homo sapiens (Human)	PC2,Autosomal dominant polycystic kidney disease type II protein,Polycystic kidney disease 2 protein,Polycystwin,R48321,Transient receptor potential cation channel subfamily P member 2
2	B (B)	Polycystin-1	polymer	1153	127024.8	1	UniProt (P98161) Pfam (PF01477) Pfam (PF20519) Pfam (PF08016)	Homo sapiens (Human)	PC1,Autosomal dominant polycystic kidney disease 1 protein

Sequence modifications

A, F, G: 185 - 723 (UniProt: Q13563)

PDB	External Database	Details
Met 147	-	expression tag
Gly 148	-	expression tag
Ser 149	-	expression tag
Ala 150	-	expression tag
Gly 151	-	expression tag
Trp 152	-	expression tag
Ser 153	-	expression tag
His 154	-	expression tag
Pro 155	-	expression tag
Gln 156	-	expression tag
Phe 157	-	expression tag
Glu 158	-	expression tag
Lys 159	-	expression tag
Gly 160	-	expression tag
Gly 161	-	expression tag
Gly 162	-	expression tag
Ser 163	-	expression tag
Gly 164	-	expression tag
Gly 165	-	expression tag
Gly 166	-	expression tag
Ser 167	-	expression tag
Gly 168	-	expression tag
Gly 169	-	expression tag
Ser 170	-	expression tag
Ala 171	-	expression tag
Trp 172	-	expression tag
Ser 173	-	expression tag
His 174	-	expression tag
Pro 175	-	expression tag
Gln 176	-	expression tag
Phe 177	-	expression tag
Glu 178	-	expression tag
Lys 179	-	expression tag
Gly 180	-	expression tag
Ser 181	-	expression tag
Ala 182	-	expression tag
Ala 183	-	expression tag
Ala 184	-	expression tag

B: 3049 - 4169 (UniProt: P98161)

PDB	External Database	Details
Met 3017	-	expression tag
Gly 3018	-	expression tag
Ser 3019	-	expression tag
Ala 3020	-	expression tag
Gly 3021	-	expression tag
Asp 3022	-	expression tag
Tyr 3023	-	expression tag
Lys 3024	-	expression tag
Asp 3025	-	expression tag
His 3026	-	expression tag
Asp 3027	-	expression tag
Gly 3028	-	expression tag
Asp 3029	-	expression tag
Tyr 3030	-	expression tag
Lys 3031	-	expression tag
Asp 3032	-	expression tag
His 3033	-	expression tag
Asp 3034	-	expression tag
Ile 3035	-	expression tag
Asp 3036	-	expression tag
Tyr 3037	-	expression tag
Lys 3038	-	expression tag
Asp 3039	-	expression tag
Asp 3040	-	expression tag
Asp 3041	-	expression tag
Asp 3042	-	expression tag
Lys 3043	-	expression tag
Gly 3044	-	expression tag
Ser 3045	-	expression tag
Ala 3046	-	expression tag
Ala 3047	-	expression tag
Ala 3048	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	326895.1
All*	Total formula weight	326895.1

*Water molecules are not included.