6A70

Structure of the human PKD1/PKD2 complex

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005509	molecular_function	calcium ion binding
A	0016020	cellular_component	membrane
B	0016020	cellular_component	membrane
F	0005509	molecular_function	calcium ion binding
F	0016020	cellular_component	membrane
G	0005509	molecular_function	calcium ion binding
G	0016020	cellular_component	membrane

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	63
Details	TRANSMEM: Helical; Name=S1 => ECO:0000269|PubMed:27768895, ECO:0000269|PubMed:27991905, ECO:0000269|PubMed:28092368

Chain	Residue	Details
A	VAL220-MET241
B	GLY4028-VAL4048
B	TRP4091-TYR4110
F	VAL220-MET241
G	VAL220-MET241
B	GLY3560-PHE3580
B	GLY3583-TRP3603
B	ARG3666-LEU3686
B	LEU3902-TRP3922
B	TRP3936-LEU3956
B	SER3985-GLN4005

---

site_id	SWS_FT_FI2
Number of Residues	807
Details	TOPO_DOM: Extracellular => ECO:0000269|PubMed:27768895, ECO:0000269|PubMed:27991905, ECO:0000269|PubMed:28092368

Chain	Residue	Details
A	MET242-THR468
G	TYR527-ALA552
G	GLY620-GLU631
G	ALA647-ARG654
A	TYR527-ALA552
A	GLY620-GLU631
A	ALA647-ARG654
F	MET242-THR468
F	TYR527-ALA552
F	GLY620-GLU631
F	ALA647-ARG654
G	MET242-THR468

---

site_id	SWS_FT_FI3
Number of Residues	60
Details	TRANSMEM: Helical; Name=S2 => ECO:0000269|PubMed:27768895, ECO:0000269|PubMed:27991905, ECO:0000269|PubMed:28092368

Chain	Residue	Details
A	PHE469-VAL489
F	PHE469-VAL489
G	PHE469-VAL489
B	GLY3957-SER3984
B	SER4049-LEU4090

---

site_id	SWS_FT_FI4
Number of Residues	114
Details	TOPO_DOM: Cytoplasmic => ECO:0000269|PubMed:27768895, ECO:0000269|PubMed:27991905, ECO:0000269|PubMed:28092368

Chain	Residue	Details
A	GLU490-SER505
A	PHE574-LEU597
F	GLU490-SER505
F	PHE574-LEU597
G	GLU490-SER505
G	PHE574-LEU597

---

site_id	SWS_FT_FI5
Number of Residues	60
Details	TRANSMEM: Helical; Name=S3 => ECO:0000269|PubMed:27768895, ECO:0000269|PubMed:27991905, ECO:0000269|PubMed:28092368

Chain	Residue	Details
A	PHE506-ILE526
F	PHE506-ILE526
G	PHE506-ILE526

---

site_id	SWS_FT_FI6
Number of Residues	60
Details	TRANSMEM: Helical; Name=S4 => ECO:0000269|PubMed:27768895, ECO:0000269|PubMed:27991905, ECO:0000269|PubMed:28092368

Chain	Residue	Details
A	TYR553-LEU573
F	TYR553-LEU573
G	TYR553-LEU573

---

site_id	SWS_FT_FI7
Number of Residues	63
Details	TRANSMEM: Helical; Name=5 => ECO:0000269|PubMed:27768895, ECO:0000269|PubMed:27991905, ECO:0000269|PubMed:28092368

Chain	Residue	Details
A	PHE598-PHE619
F	PHE598-PHE619
G	PHE598-PHE619

---

site_id	SWS_FT_FI8
Number of Residues	42
Details	INTRAMEM: Pore-forming => ECO:0000269|PubMed:27768895, ECO:0000269|PubMed:27991905, ECO:0000269|PubMed:28092368

Chain	Residue	Details
A	CYS632-PHE646
F	CYS632-PHE646
G	CYS632-PHE646

---

site_id	SWS_FT_FI9
Number of Residues	60
Details	TRANSMEM: Helical; Name=S6 => ECO:0000269|PubMed:27768895, ECO:0000269|PubMed:27991905, ECO:0000269|PubMed:28092368

Chain	Residue	Details
A	VAL655-MET675
F	VAL655-MET675
G	VAL655-MET675

---

site_id	SWS_FT_FI10
Number of Residues	6
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:28092368

Chain	Residue	Details
A	ASN299
A	ASN305
F	ASN299
F	ASN305
G	ASN299
G	ASN305

---

site_id	SWS_FT_FI11
Number of Residues	3
Details	CARBOHYD: N-linked (GlcNAc...) (complex) asparagine => ECO:0000269|PubMed:19139490, ECO:0000269|PubMed:27768895, ECO:0000269|PubMed:27991905, ECO:0000269|PubMed:28092368

Chain	Residue	Details
A	ASN328
F	ASN328
G	ASN328

---

site_id	SWS_FT_FI12
Number of Residues	6
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:27768895, ECO:0000269|PubMed:27991905, ECO:0000269|PubMed:28092368

Chain	Residue	Details
A	ASN362
A	ASN375
F	ASN362
F	ASN375
G	ASN362
G	ASN375

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