6A5X
FXR-LBD with HNC180 and SRC1
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Bile acid receptor | polymer | 229 | 26854.7 | 1 | UniProt (Q96RI1) Pfam (PF00104) | Homo sapiens (Human) | Farnesoid X-activated receptor,Farnesol receptor HRR-1,Nuclear receptor subfamily 1 group H member 4,Retinoid X receptor-interacting protein 14,RXR-interacting protein 14 |
| 2 | B (B) | Nuclear receptor coactivator 1 | polymer | 11 | 1416.6 | 1 | UniProt (B5MCN7) UniProt (by SIFTS) (Q15788) | Homo sapiens | |
| 3 | C, D, E, F, H (A, B) | SULFATE ION | non-polymer | 96.1 | 5 | Chemie (SO4) | |||
| 4 | G (A) | 2-[(1R,5S)-9-[[3-[2,6-bis(chloranyl)phenyl]-5-cyclopropyl-1,2-oxazol-4-yl]methoxy]-3-azabicyclo[3.3.1]nonan-3-yl]-1,3-benzothiazole-6-carboxylic acid | non-polymer | 584.5 | 1 | Chemie (9R3) | |||
| 5 | I (A) | water | water | 18.0 | 11 | Chemie (HOH) |
Sequence modifications
A: 244 - 472 (UniProt: Q96RI1)
| PDB | External Database | Details |
|---|---|---|
| Glu 432 | Cys 446 | engineered mutation |
| Glu 466 | Cys 480 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 28271.4 | |
| Non-Polymers* | Number of molecules | 6 |
| Total formula weight | 1064.8 | |
| All* | Total formula weight | 29336.2 |
