5ZM8

Crystal structure of ORP2-ORD in complex with PI(4,5)P2

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Oxysterol-binding protein-related protein 2	polymer	455	52773.6	2	UniProt (Q9H1P3) Pfam (PF01237)	Homo sapiens (Human)	OSBP-related protein 2
2	C, D (A, B)	[(2~{S})-1-octadecanoyloxy-3-[oxidanyl-[(1~{R},2~{R},3~{S},4~{S},5~{S},6~{S})-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propan-2-yl] icosa-5,8,11,14-tetraenoate	non-polymer		1047.1	2	Chemie (IEP)
3	E, F (A, B)	water	water		18.0	155	Chemie (HOH)

Sequence modifications

A, B: 49 - 480 (UniProt: Q9H1P3)

PDB	External Database	Details
Met 26	-	initiating methionine
Gly 27	-	expression tag
Ser 28	-	expression tag
Ser 29	-	expression tag
His 30	-	expression tag
His 31	-	expression tag
His 32	-	expression tag
His 33	-	expression tag
His 34	-	expression tag
His 35	-	expression tag
Ser 36	-	expression tag
Gln 37	-	expression tag
Asp 38	-	expression tag
Leu 39	-	expression tag
Glu 40	-	expression tag
Val 41	-	expression tag
Leu 42	-	expression tag
Phe 43	-	expression tag
Gln 44	-	expression tag
Gly 45	-	expression tag
Pro 46	-	expression tag
His 47	-	expression tag
Met 48	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	105547.3
Non-Polymers*	Number of molecules	2
	Total formula weight	2094.2
All*	Total formula weight	107641.5

*Water molecules are not included.