5ZM8

Crystal structure of ORP2-ORD in complex with PI(4,5)P2

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005515	molecular_function	protein binding
A	0005546	molecular_function	phosphatidylinositol-4,5-bisphosphate binding
A	0005737	cellular_component	cytoplasm
A	0005811	cellular_component	lipid droplet
A	0005829	cellular_component	cytosol
A	0005886	cellular_component	plasma membrane
A	0006699	biological_process	bile acid biosynthetic process
A	0006869	biological_process	lipid transport
A	0007009	biological_process	plasma membrane organization
A	0008289	molecular_function	lipid binding
A	0008526	molecular_function	phosphatidylinositol transfer activity
A	0009898	cellular_component	cytoplasmic side of plasma membrane
A	0010807	biological_process	regulation of synaptic vesicle priming
A	0015485	molecular_function	cholesterol binding
A	0015914	biological_process	phospholipid transport
A	0030301	biological_process	cholesterol transport
A	0032367	biological_process	intracellular cholesterol transport
A	0051289	biological_process	protein homotetramerization
A	0097038	cellular_component	perinuclear endoplasmic reticulum
A	0098831	cellular_component	presynaptic active zone cytoplasmic component
A	0098978	cellular_component	glutamatergic synapse
A	0099509	biological_process	regulation of presynaptic cytosolic calcium ion concentration
A	0120009	biological_process	intermembrane lipid transfer
A	0120015	molecular_function	sterol transfer activity
A	0120020	molecular_function	cholesterol transfer activity
B	0005515	molecular_function	protein binding
B	0005546	molecular_function	phosphatidylinositol-4,5-bisphosphate binding
B	0005737	cellular_component	cytoplasm
B	0005811	cellular_component	lipid droplet
B	0005829	cellular_component	cytosol
B	0005886	cellular_component	plasma membrane
B	0006699	biological_process	bile acid biosynthetic process
B	0006869	biological_process	lipid transport
B	0007009	biological_process	plasma membrane organization
B	0008289	molecular_function	lipid binding
B	0008526	molecular_function	phosphatidylinositol transfer activity
B	0009898	cellular_component	cytoplasmic side of plasma membrane
B	0010807	biological_process	regulation of synaptic vesicle priming
B	0015485	molecular_function	cholesterol binding
B	0015914	biological_process	phospholipid transport
B	0030301	biological_process	cholesterol transport
B	0032367	biological_process	intracellular cholesterol transport
B	0051289	biological_process	protein homotetramerization
B	0097038	cellular_component	perinuclear endoplasmic reticulum
B	0098831	cellular_component	presynaptic active zone cytoplasmic component
B	0098978	cellular_component	glutamatergic synapse
B	0099509	biological_process	regulation of presynaptic cytosolic calcium ion concentration
B	0120009	biological_process	intermembrane lipid transfer
B	0120015	molecular_function	sterol transfer activity
B	0120020	molecular_function	cholesterol transfer activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	16
Details	binding site for residue IEP A 501

Chain	Residue
A	VAL76
A	TRP207
A	GLY208
A	LYS209
A	ILE243
A	GLU427
A	ARG431
A	ARG434
A	LYS90
A	ILE91
A	THR92
A	MET93
A	HIS178
A	HIS179
A	PHE206
A	PHE206

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site_id	AC2
Number of Residues	13
Details	binding site for residue IEP B 501

Chain	Residue
B	PHE74
B	LEU88
B	SER89
B	MET93
B	THR148
B	GLY149
B	PRO151
B	ASN153
B	PRO154
B	HIS178
B	HIS179
B	GLU427
B	ARG431

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Functional Information from PROSITE/UniProt

site_id	PS01013
Number of Residues	11
Details	OSBP Oxysterol-binding protein family signature. EQvSHHPPi.SA

Chain	Residue	Details
A	GLU174-ALA184

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	6
Details	BINDING: BINDING => ECO:0000269|PubMed:30581148, ECO:0007744|PDB:5ZM8

Chain	Residue	Details
A	LYS90
A	HIS178
A	GLU427
B	LYS90
B	HIS178
B	GLU427

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