5ZKP
Crystal structure of the human platelet-activating factor receptor in complex with SR 27417
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Platelet-activating factor receptor,Flavodoxin,Platelet-activating factor receptor | polymer | 466 | 52430.5 | 1 | UniProt (P25105) UniProt (P00323) Pfam (PF00001) Pfam (PF00258) | Homo sapiens (Human) | PAFr,PAFr |
| 2 | B (A) | N1,N1-dimethyl-N2-[(pyridin-3-yl)methyl]-N2-{4-[2,4,6-tri(propan-2-yl)phenyl]-1,3-thiazol-2-yl}ethane-1,2-diamine | non-polymer | 464.7 | 1 | Chemie (9ER) | |||
| 3 | C (A) | FLAVIN MONONUCLEOTIDE | non-polymer | 456.3 | 1 | Chemie (FMN) |
Sequence modifications
A: 2 - 216 (UniProt: P25105)
A: 1001 - 1147 (UniProt: P00323)
A: 224 - 316 (UniProt: P25105)
| PDB | External Database | Details |
|---|---|---|
| Gly -1 | - | expression tag |
| Ala 0 | - | expression tag |
| Pro 1 | - | expression tag |
| Tyr 116 | Phe 116 | engineered mutation |
| Asp 169 | Asn 169 | engineered mutation |
| PDB | External Database | Details |
|---|---|---|
| Ala 1001 | Pro 2 | engineered mutation |
| Trp 1097 | Tyr 98 | engineered mutation |
| PDB | External Database | Details |
|---|---|---|
| Asp 230 | Ala 230 | engineered mutation |
| Ala 234 | Val 234 | engineered mutation |
| Asn 289 | Asp 289 | engineered mutation |
| Glu 317 | - | expression tag |
| Phe 318 | - | expression tag |
| Leu 319 | - | expression tag |
| Glu 320 | - | expression tag |
| Val 321 | - | expression tag |
| Leu 322 | - | expression tag |
| Phe 323 | - | expression tag |
| Gln 324 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 52430.5 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 921.1 | |
| All* | Total formula weight | 53351.5 |
