5ZG0
Crystal structure of the GluA2o LBD in complex with glutamate and Compound-1
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D, E... (A, B, C, D, E...) | Glutamate receptor 2 | polymer | 263 | 29337.8 | 6 | UniProt (P42262) Pfam (PF10613) Pfam (PF00060) | Homo sapiens (Human) | GluR-2,AMPA-selective glutamate receptor 2,GluR-B,GluR-K2,Glutamate receptor ionotropic,AMPA 2,GluA2 |
| 2 | CA, G, J, N, R... (F, A, B, C, D...) | GLUTAMIC ACID | non-polymer | 147.1 | 6 | Chemie (GLU) | |||
| 3 | AA, BA, DA, EA, FA... (E, F, A, B, C...) | ZINC ION | non-polymer | 65.4 | 12 | Chemie (ZN) | |||
| 4 | I, M, Y (B, C, E) | 9-{4-[(propan-2-yl)oxy]phenyl}-3,4-dihydro-2H-2lambda~6~-pyrido[2,1-c][1,2,4]thiadiazine-2,2-dione | non-polymer | 318.4 | 3 | Chemie (9C3) | |||
| 5 | GA, HA, P, Q, V... (F, C, D) | ACETATE ION | non-polymer | 59.0 | 7 | Chemie (ACT) | |||
| 6 | IA, JA, KA, LA, MA... (A, B, C, D, E...) | water | water | 18.0 | 1093 | Chemie (HOH) |
Sequence modifications
A, B, C, D, E, F: 413 - 526 (UniProt: P42262)
A, B, C, D, E, F: 653 - 796 (UniProt: P42262)
| PDB | External Database | Details |
|---|---|---|
| Gly 411 | - | expression tag |
| Ser 412 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Lys 527 | - | linker |
| Gly 641 | - | linker |
| Thr 642 | - | linker |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 6 |
| Total formula weight | 176027.0 | |
| Non-Polymers* | Number of molecules | 28 |
| Total formula weight | 3036.2 | |
| All* | Total formula weight | 179063.1 |
