5ZG0

Crystal structure of the GluA2o LBD in complex with glutamate and Compound-1

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D, E...	Glutamate receptor 2	polymer	263	29337.8	6	UniProt (P42262) Pfam (PF10613) Pfam (PF00060) In PDB	Homo sapiens (Human)	GluR-2,AMPA-selective glutamate receptor 2,GluR-B,GluR-K2,Glutamate receptor ionotropic,AMPA 2,GluA2
2	F, A, B, C, D...	GLUTAMIC ACID	non-polymer		147.1	6	Chemie (GLU)
3	E, F, A, B, C...	ZINC ION	non-polymer		65.4	12	Chemie (ZN)
4	B, C, E	9-{4-[(propan-2-yl)oxy]phenyl}-3,4-dihydro-2H-2lambda~6~-pyrido[2,1-c][1,2,4]thiadiazine-2,2-dione	non-polymer		318.4	3	Chemie (9C3)
5	F, C, D	ACETATE ION	non-polymer		59.0	7	Chemie (ACT)
6		water	water		18.0	1093	Chemie (HOH)

Sequence modifications

A, B, C, D, E, F: 413 - 526 (UniProt: P42262)

PDB	External Database	Details
Gly 411	-	expression tag
Ser 412	-	expression tag

A, B, C, D, E, F: 653 - 796 (UniProt: P42262)

PDB	External Database	Details
Lys 527	-	linker
Gly 641	-	linker
Thr 642	-	linker

Contents of the asymmetric unit

Polymers	Number of chains	6
	Total formula weight	176027.0
Non-Polymers*	Number of molecules	28
	Total formula weight	3036.2
All*	Total formula weight	179063.1

*Water molecules are not included.