5X2A
Crystal structure of EGFR 696-1022 T790M/V948R in complex with SKLB(3)
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B, C, D | Epidermal growth factor receptor | polymer | 331 | 37724.6 | 4 | UniProt (P00533) Pfam (PF07714) In PDB | Homo sapiens (Human) | Proto-oncogene c-ErbB-1,Receptor tyrosine-protein kinase erbB-1 |
2 | A | CHLORIDE ION | non-polymer | 35.5 | 1 | Chemie (CL) | |||
3 | A, B, C | 1,2-ETHANEDIOL | non-polymer | 62.1 | 12 | Chemie (EDO) | |||
4 | A, B, C | N2-[4-(4-methylpiperazin-1-yl)phenyl]-N8-phenyl-9-propan-2-yl-purine-2,8-diamine | non-polymer | 442.6 | 3 | Chemie (7XO) | |||
5 | A, B, D | PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER | non-polymer | 506.2 | 3 | Chemie (ANP) | |||
6 | D, A, B | MAGNESIUM ION | non-polymer | 24.3 | 4 | Chemie (MG) | |||
7 | water | water | 18.0 | 1003 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 696 - 1022 (UniProt: P00533)
PDB | External Database | Details |
---|---|---|
Gly 692 | - | expression tag |
Ser 693 | - | expression tag |
Thr 694 | - | expression tag |
Ser 695 | - | expression tag |
Met 790 | Thr 790 | engineered mutation |
Arg 948 | Val 948 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 4 |
Total formula weight | 150898.4 | |
Non-Polymers* | Number of molecules | 23 |
Total formula weight | 3723.8 | |
All* | Total formula weight | 154622.1 |