5WKC

Saccharomyces cerevisiae acetohydroxyacid synthase in complex with the herbicide penoxsulam

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C (A, B, E)	Acetolactate synthase catalytic subunit, mitochondrial	polymer	677	73597.7	3	UniProt (P07342) Pfam (PF02776) Pfam (PF00205) Pfam (PF02775)	Saccharomyces cerevisiae S288c (Baker's yeast)	Acetohydroxy-acid synthase catalytic subunit,ALS
2	D (D)	Acetolactate synthase catalytic subunit, mitochondrial	polymer	677	73613.7	1	UniProt (P07342) Pfam (PF02776) Pfam (PF00205) Pfam (PF02775)	Saccharomyces cerevisiae S288c (Baker's yeast)	Acetohydroxy-acid synthase catalytic subunit,ALS
3	E, J, O, T (A, B, E, D)	MAGNESIUM ION	non-polymer		24.3	4	Chemie (MG)
4	F, K, P, U (A, B, E, D)	2-(2,2-difluoroethoxy)-N-(5,8-dimethoxy[1,2,4]triazolo[1,5-c]pyrimidin-2-yl)-6-(trifluoromethyl)benzenesulfonamide	non-polymer		483.4	4	Chemie (PXD)
5	G, L, Q, V (A, B, E, D)	FLAVIN-ADENINE DINUCLEOTIDE	non-polymer		785.5	4	Chemie (FAD)
6	H, N, S (A, B, E)	ETHANEPEROXOIC ACID	non-polymer		76.1	3	Chemie (F50)
7	I (A)	2-[3-[(4-azanyl-2-methyl-pyrimidin-5-yl)methyl]-2-[(1~{S})-1-(dioxidanyl)-1-oxidanyl-ethyl]-4-methyl-1,3-thiazol-5-yl]ethyl phosphono hydrogen phosphate	non-polymer		501.4	1	Chemie (AUJ)
8	M, R, W (B, E, D)	(3Z)-4-{[(4-AMINO-2-METHYLPYRIMIDIN-5-YL)METHYL]AMINO}-3-MERCAPTOPENT-3-EN-1-YL TRIHYDROGEN DIPHOSPHATE	non-polymer		412.3	3	Chemie (TP9)
9	AA, X, Y, Z (D, A, B, E)	water	water		18.0	1172	Chemie (HOH)

Sequence modifications

A, B, E: 58 - 687 (UniProt: P07342)

PDB	External Database	Details
Met 11	-	initiating methionine
His 12	-	expression tag
His 13	-	expression tag
His 14	-	expression tag
His 15	-	expression tag
His 16	-	expression tag
His 17	-	expression tag
Ser 18	-	expression tag
Ser 19	-	expression tag
Gly 20	-	expression tag
Leu 21	-	expression tag
Val 22	-	expression tag
Pro 23	-	expression tag
Arg 24	-	expression tag
Gly 25	-	expression tag
Ser 26	-	expression tag
Gly 27	-	expression tag
Met 28	-	expression tag
Lys 29	-	expression tag
Glu 30	-	expression tag
Thr 31	-	expression tag
Ala 32	-	expression tag
Ala 33	-	expression tag
Ala 34	-	expression tag
Lys 35	-	expression tag
Phe 36	-	expression tag
Glu 37	-	expression tag
Arg 38	-	expression tag
Gln 39	-	expression tag
His 40	-	expression tag
Met 41	-	expression tag
Asp 42	-	expression tag
Ser 43	-	expression tag
Pro 44	-	expression tag
Asp 45	-	expression tag
Leu 46	-	expression tag
Gly 47	-	expression tag
Thr 48	-	expression tag
Asp 49	-	expression tag
Asp 50	-	expression tag
Asp 51	-	expression tag
Asp 52	-	expression tag
Lys 53	-	expression tag
Ala 54	-	expression tag
Met 55	-	expression tag
Gly 56	-	expression tag
Ser 57	-	expression tag

D: 58 - 687 (UniProt: P07342)

PDB	External Database	Details
Met 11	-	initiating methionine
His 12	-	expression tag
His 13	-	expression tag
His 14	-	expression tag
His 15	-	expression tag
His 16	-	expression tag
His 17	-	expression tag
Ser 18	-	expression tag
Ser 19	-	expression tag
Gly 20	-	expression tag
Leu 21	-	expression tag
Val 22	-	expression tag
Pro 23	-	expression tag
Arg 24	-	expression tag
Gly 25	-	expression tag
Ser 26	-	expression tag
Gly 27	-	expression tag
Met 28	-	expression tag
Lys 29	-	expression tag
Glu 30	-	expression tag
Thr 31	-	expression tag
Ala 32	-	expression tag
Ala 33	-	expression tag
Ala 34	-	expression tag
Lys 35	-	expression tag
Phe 36	-	expression tag
Glu 37	-	expression tag
Arg 38	-	expression tag
Gln 39	-	expression tag
His 40	-	expression tag
Met 41	-	expression tag
Asp 42	-	expression tag
Ser 43	-	expression tag
Pro 44	-	expression tag
Asp 45	-	expression tag
Leu 46	-	expression tag
Gly 47	-	expression tag
Thr 48	-	expression tag
Asp 49	-	expression tag
Asp 50	-	expression tag
Asp 51	-	expression tag
Asp 52	-	expression tag
Lys 53	-	expression tag
Ala 54	-	expression tag
Met 55	-	expression tag
Gly 56	-	expression tag
Ser 57	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	294406.6
Non-Polymers*	Number of molecules	19
	Total formula weight	7139.3
All*	Total formula weight	301545.9

*Water molecules are not included.