5WKC
Saccharomyces cerevisiae acetohydroxyacid synthase in complex with the herbicide penoxsulam
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0000287 | molecular_function | magnesium ion binding |
A | 0003824 | molecular_function | catalytic activity |
A | 0003984 | molecular_function | acetolactate synthase activity |
A | 0005739 | cellular_component | mitochondrion |
A | 0005948 | cellular_component | acetolactate synthase complex |
A | 0008652 | biological_process | amino acid biosynthetic process |
A | 0009082 | biological_process | branched-chain amino acid biosynthetic process |
A | 0009097 | biological_process | isoleucine biosynthetic process |
A | 0009099 | biological_process | valine biosynthetic process |
A | 0016740 | molecular_function | transferase activity |
A | 0030976 | molecular_function | thiamine pyrophosphate binding |
A | 0046872 | molecular_function | metal ion binding |
A | 0050660 | molecular_function | flavin adenine dinucleotide binding |
B | 0000287 | molecular_function | magnesium ion binding |
B | 0003824 | molecular_function | catalytic activity |
B | 0003984 | molecular_function | acetolactate synthase activity |
B | 0005739 | cellular_component | mitochondrion |
B | 0005948 | cellular_component | acetolactate synthase complex |
B | 0008652 | biological_process | amino acid biosynthetic process |
B | 0009082 | biological_process | branched-chain amino acid biosynthetic process |
B | 0009097 | biological_process | isoleucine biosynthetic process |
B | 0009099 | biological_process | valine biosynthetic process |
B | 0016740 | molecular_function | transferase activity |
B | 0030976 | molecular_function | thiamine pyrophosphate binding |
B | 0046872 | molecular_function | metal ion binding |
B | 0050660 | molecular_function | flavin adenine dinucleotide binding |
D | 0000287 | molecular_function | magnesium ion binding |
D | 0003824 | molecular_function | catalytic activity |
D | 0003984 | molecular_function | acetolactate synthase activity |
D | 0005739 | cellular_component | mitochondrion |
D | 0005948 | cellular_component | acetolactate synthase complex |
D | 0008652 | biological_process | amino acid biosynthetic process |
D | 0009082 | biological_process | branched-chain amino acid biosynthetic process |
D | 0009097 | biological_process | isoleucine biosynthetic process |
D | 0009099 | biological_process | valine biosynthetic process |
D | 0016740 | molecular_function | transferase activity |
D | 0030976 | molecular_function | thiamine pyrophosphate binding |
D | 0046872 | molecular_function | metal ion binding |
D | 0050660 | molecular_function | flavin adenine dinucleotide binding |
E | 0000287 | molecular_function | magnesium ion binding |
E | 0003824 | molecular_function | catalytic activity |
E | 0003984 | molecular_function | acetolactate synthase activity |
E | 0005739 | cellular_component | mitochondrion |
E | 0005948 | cellular_component | acetolactate synthase complex |
E | 0008652 | biological_process | amino acid biosynthetic process |
E | 0009082 | biological_process | branched-chain amino acid biosynthetic process |
E | 0009097 | biological_process | isoleucine biosynthetic process |
E | 0009099 | biological_process | valine biosynthetic process |
E | 0016740 | molecular_function | transferase activity |
E | 0030976 | molecular_function | thiamine pyrophosphate binding |
E | 0046872 | molecular_function | metal ion binding |
E | 0050660 | molecular_function | flavin adenine dinucleotide binding |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 5 |
Details | binding site for residue MG A 701 |
Chain | Residue |
A | ASP550 |
A | ASN577 |
A | GLU579 |
A | AUJ705 |
A | HOH845 |
site_id | AC2 |
Number of Residues | 15 |
Details | binding site for residue PXD A 702 |
Chain | Residue |
A | VAL583 |
A | TRP586 |
A | FAD703 |
A | AUJ705 |
D | GLY116 |
D | ALA117 |
D | SER163 |
D | VAL191 |
D | PHE201 |
D | LYS251 |
D | HOH947 |
A | MET354 |
A | ASP379 |
A | ARG380 |
A | MET582 |
site_id | AC3 |
Number of Residues | 36 |
Details | binding site for residue FAD A 703 |
Chain | Residue |
A | ASP180 |
A | ARG241 |
A | GLY307 |
A | ALA308 |
A | GLY309 |
A | ASN312 |
A | THR334 |
A | LEU335 |
A | GLN336 |
A | LEU352 |
A | GLY353 |
A | MET354 |
A | HIS355 |
A | GLY374 |
A | ALA375 |
A | ARG376 |
A | ARG380 |
A | VAL381 |
A | GLU407 |
A | VAL408 |
A | ASN412 |
A | GLY425 |
A | ASP426 |
A | ALA427 |
A | GLN501 |
A | MET502 |
A | GLY520 |
A | GLY521 |
A | PXD702 |
A | HOH828 |
A | HOH831 |
A | HOH856 |
A | HOH863 |
A | HOH923 |
A | HOH937 |
D | PHE201 |
site_id | AC4 |
Number of Residues | 6 |
Details | binding site for residue F50 A 704 |
Chain | Residue |
A | GLY115 |
A | GLY116 |
A | GLN202 |
D | MET582 |
D | PXD702 |
D | TP9704 |
site_id | AC5 |
Number of Residues | 26 |
Details | binding site for residue AUJ A 705 |
Chain | Residue |
A | VAL497 |
A | GLY498 |
A | GLN499 |
A | HIS500 |
A | GLY523 |
A | MET525 |
A | GLY549 |
A | ASP550 |
A | ALA551 |
A | SER552 |
A | ASN577 |
A | GLU579 |
A | GLN580 |
A | GLY581 |
A | MET582 |
A | VAL583 |
A | MG701 |
A | PXD702 |
A | HOH845 |
D | TYR113 |
D | PRO114 |
D | GLY116 |
D | GLU139 |
D | PRO165 |
D | ASN169 |
D | GLN202 |
site_id | AC6 |
Number of Residues | 5 |
Details | binding site for residue MG B 701 |
Chain | Residue |
B | ASP550 |
B | ASN577 |
B | GLU579 |
B | TP9704 |
B | HOH897 |
site_id | AC7 |
Number of Residues | 16 |
Details | binding site for residue PXD B 702 |
Chain | Residue |
B | FAD703 |
B | HOH1001 |
B | HOH1060 |
E | GLY116 |
E | ALA117 |
E | VAL191 |
E | PHE201 |
E | LYS251 |
E | F50705 |
E | HOH804 |
B | MET354 |
B | ASP379 |
B | ARG380 |
B | MET582 |
B | VAL583 |
B | TRP586 |
site_id | AC8 |
Number of Residues | 34 |
Details | binding site for residue FAD B 703 |
Chain | Residue |
B | ARG241 |
B | GLY307 |
B | ALA308 |
B | GLY309 |
B | ASN312 |
B | THR334 |
B | LEU335 |
B | GLN336 |
B | LEU352 |
B | GLY353 |
B | MET354 |
B | HIS355 |
B | GLY374 |
B | ALA375 |
B | ARG376 |
B | ARG380 |
B | VAL381 |
B | GLU407 |
B | VAL408 |
B | ASN412 |
B | GLY425 |
B | ASP426 |
B | ALA427 |
B | GLN501 |
B | MET502 |
B | GLY520 |
B | GLY521 |
B | PXD702 |
B | HOH852 |
B | HOH889 |
B | HOH946 |
B | HOH989 |
B | HOH1050 |
E | PHE201 |
site_id | AC9 |
Number of Residues | 24 |
Details | binding site for residue TP9 B 704 |
Chain | Residue |
B | VAL497 |
B | GLY498 |
B | GLN499 |
B | HIS500 |
B | GLY523 |
B | MET525 |
B | GLY549 |
B | ASP550 |
B | ALA551 |
B | SER552 |
B | ASN577 |
B | GLU579 |
B | GLN580 |
B | GLY581 |
B | MET582 |
B | VAL583 |
B | MG701 |
B | HOH897 |
E | TYR113 |
E | PRO114 |
E | GLU139 |
E | ASN169 |
E | GLN202 |
E | F50705 |
site_id | AD1 |
Number of Residues | 6 |
Details | binding site for residue F50 B 705 |
Chain | Residue |
B | GLY115 |
B | GLY116 |
B | GLN202 |
E | MET582 |
E | PXD702 |
E | TP9704 |
site_id | AD2 |
Number of Residues | 5 |
Details | binding site for residue MG E 701 |
Chain | Residue |
E | ASP550 |
E | ASN577 |
E | GLU579 |
E | TP9704 |
E | HOH831 |
site_id | AD3 |
Number of Residues | 13 |
Details | binding site for residue PXD E 702 |
Chain | Residue |
B | GLY116 |
B | ALA117 |
B | VAL191 |
B | PHE201 |
B | LYS251 |
B | F50705 |
E | MET354 |
E | ASP379 |
E | ARG380 |
E | MET582 |
E | VAL583 |
E | TRP586 |
E | FAD703 |
site_id | AD4 |
Number of Residues | 35 |
Details | binding site for residue FAD E 703 |
Chain | Residue |
B | PHE201 |
E | ASP180 |
E | ARG241 |
E | GLY307 |
E | ALA308 |
E | GLY309 |
E | ASN312 |
E | THR334 |
E | LEU335 |
E | GLN336 |
E | LEU352 |
E | GLY353 |
E | MET354 |
E | HIS355 |
E | GLY374 |
E | ALA375 |
E | ARG376 |
E | ARG380 |
E | VAL381 |
E | GLU407 |
E | VAL408 |
E | ASN412 |
E | GLY425 |
E | ASP426 |
E | ALA427 |
E | GLN501 |
E | MET502 |
E | GLY520 |
E | GLY521 |
E | PXD702 |
E | HOH809 |
E | HOH821 |
E | HOH835 |
E | HOH895 |
E | HOH918 |
site_id | AD5 |
Number of Residues | 24 |
Details | binding site for residue TP9 E 704 |
Chain | Residue |
B | PRO114 |
B | GLU139 |
B | PRO165 |
B | ASN169 |
B | GLN202 |
B | F50705 |
E | VAL497 |
E | GLY498 |
E | GLN499 |
E | HIS500 |
E | GLY523 |
E | MET525 |
E | GLY549 |
E | ASP550 |
E | ALA551 |
E | SER552 |
E | ASN577 |
E | GLU579 |
E | GLN580 |
E | GLY581 |
E | MET582 |
E | VAL583 |
E | MG701 |
E | HOH831 |
site_id | AD6 |
Number of Residues | 5 |
Details | binding site for residue F50 E 705 |
Chain | Residue |
B | MET582 |
B | PXD702 |
B | TP9704 |
E | GLY116 |
E | GLN202 |
site_id | AD7 |
Number of Residues | 5 |
Details | binding site for residue MG D 701 |
Chain | Residue |
D | ASP550 |
D | ASN577 |
D | GLU579 |
D | TP9704 |
D | HOH922 |
site_id | AD8 |
Number of Residues | 15 |
Details | binding site for residue PXD D 702 |
Chain | Residue |
A | GLY116 |
A | ALA117 |
A | VAL191 |
A | PHE201 |
A | LYS251 |
A | F50704 |
A | HOH822 |
D | MET354 |
D | ASP379 |
D | ARG380 |
D | MET582 |
D | VAL583 |
D | TRP586 |
D | FAD703 |
D | HOH1066 |
site_id | AD9 |
Number of Residues | 36 |
Details | binding site for residue FAD D 703 |
Chain | Residue |
A | PHE201 |
D | ASP180 |
D | ARG241 |
D | GLY307 |
D | ALA308 |
D | GLY309 |
D | ASN312 |
D | THR334 |
D | LEU335 |
D | GLN336 |
D | LEU352 |
D | GLY353 |
D | MET354 |
D | HIS355 |
D | GLY374 |
D | ALA375 |
D | ARG376 |
D | ARG380 |
D | VAL381 |
D | GLU407 |
D | VAL408 |
D | ASN412 |
D | GLY425 |
D | ASP426 |
D | ALA427 |
D | GLN501 |
D | SME502 |
D | GLY520 |
D | GLY521 |
D | MET582 |
D | PXD702 |
D | HOH815 |
D | HOH877 |
D | HOH890 |
D | HOH944 |
D | HOH1005 |
site_id | AE1 |
Number of Residues | 25 |
Details | binding site for residue TP9 D 704 |
Chain | Residue |
A | TYR113 |
A | PRO114 |
A | GLU139 |
A | PRO165 |
A | ASN169 |
A | GLN202 |
A | F50704 |
D | VAL497 |
D | GLY498 |
D | GLN499 |
D | HIS500 |
D | GLY523 |
D | MET525 |
D | GLY549 |
D | ASP550 |
D | ALA551 |
D | SER552 |
D | ASN577 |
D | GLU579 |
D | GLN580 |
D | GLY581 |
D | MET582 |
D | VAL583 |
D | MG701 |
D | HOH922 |
Functional Information from PROSITE/UniProt
site_id | PS00187 |
Number of Residues | 20 |
Details | TPP_ENZYMES Thiamine pyrophosphate enzymes signature. IGaqvakPeslvIdIdGDAS |
Chain | Residue | Details |
D | ILE533-SER552 | |
A | ILE533-SER552 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 4 |
Details | BINDING: |
Chain | Residue | Details |
D | GLU139 | |
E | ASP550 | |
E | ASN577 | |
E | GLU579 | |
D | ASP550 | |
D | ASN577 | |
D | GLU579 | |
B | GLU139 | |
B | ASP550 | |
B | ASN577 | |
B | GLU579 | |
E | GLU139 |
site_id | SWS_FT_FI2 |
Number of Residues | 3 |
Details | BINDING: BINDING => ECO:0000269|PubMed:12496246 |
Chain | Residue | Details |
D | ARG241 | |
D | HIS355 | |
D | GLU407 | |
B | ARG241 | |
B | HIS355 | |
B | GLU407 | |
E | ARG241 | |
E | HIS355 | |
E | GLU407 |
Catalytic Information from CSA
site_id | MCSA1 |
Number of Residues | 5 |
Details | M-CSA 289 |
Chain | Residue | Details |
D | GLU139 | hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor |
D | PHE201 | single electron acceptor, single electron donor, single electron relay |
D | GLN202 | electrostatic stabiliser, hydrogen bond donor |
D | LYS251 | steric locator |
D | MET582 | polar interaction, steric role |
site_id | MCSA2 |
Number of Residues | 5 |
Details | M-CSA 289 |
Chain | Residue | Details |
B | GLU139 | hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor |
B | PHE201 | single electron acceptor, single electron donor, single electron relay |
B | GLN202 | electrostatic stabiliser, hydrogen bond donor |
B | LYS251 | steric locator |
B | MET582 | polar interaction, steric role |
site_id | MCSA3 |
Number of Residues | 5 |
Details | M-CSA 289 |
Chain | Residue | Details |
E | GLU139 | hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor |
E | PHE201 | single electron acceptor, single electron donor, single electron relay |
E | GLN202 | electrostatic stabiliser, hydrogen bond donor |
E | LYS251 | steric locator |
E | MET582 | polar interaction, steric role |