5WGD
Estrogen Receptor Alpha Ligand Binding Domain in Complex with Estradiol and SRC2-LP1
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Estrogen receptor | polymer | 261 | 29774.1 | 2 | UniProt (P03372) Pfam (PF00104) | Homo sapiens (Human) | ER,ER-alpha,Estradiol receptor,Nuclear receptor subfamily 3 group A member 1 |
| 2 | C (E) | (ACE)HKILHKLLQDS(NH2) | polymer | 13 | 1359.6 | 1 | synthetic construct | ||
| 3 | D (F) | (ACE)AILHKLLQDS(NH2) | polymer | 12 | 1163.4 | 1 | synthetic construct | ||
| 4 | E, F (A, B) | ESTRADIOL | non-polymer | 272.4 | 2 | Chemie (EST) | |||
| 5 | G, H, I, J (A, B, E, F) | water | water | 18.0 | 416 | Chemie (HOH) |
Sequence modifications
A, B: 297 - 554 (UniProt: P03372)
| PDB | External Database | Details |
|---|---|---|
| Met 294 | - | initiating methionine |
| Asp 295 | - | expression tag |
| Pro 296 | - | expression tag |
| Ser 537 | Tyr 364 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 62071.3 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 544.8 | |
| All* | Total formula weight | 62616.0 |
