5WGD
Estrogen Receptor Alpha Ligand Binding Domain in Complex with Estradiol and SRC2-LP1
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 7 |
| Details | binding site for residue EST A 601 |
| Chain | Residue |
| A | MET343 |
| A | LEU346 |
| A | GLU353 |
| A | ARG394 |
| A | HIS524 |
| A | LEU525 |
| A | HOH788 |
| site_id | AC2 |
| Number of Residues | 7 |
| Details | binding site for residue EST B 601 |
| Chain | Residue |
| B | GLU353 |
| B | ARG394 |
| B | HIS524 |
| B | LEU525 |
| B | HOH791 |
| B | MET343 |
| B | LEU346 |
| site_id | AC3 |
| Number of Residues | 3 |
| Details | binding site for Ligand NH2 E 13 bound to SER E 12 |
| Chain | Residue |
| E | GLN10 |
| E | ASP11 |
| E | SER12 |
| site_id | AC4 |
| Number of Residues | 4 |
| Details | binding site for Ligand NH2 F 12 bound to SER F 11 |
| Chain | Residue |
| B | LYS362 |
| F | LEU8 |
| F | ASP10 |
| F | SER11 |
| site_id | AC5 |
| Number of Residues | 4 |
| Details | binding site for Di-peptide ACE F 1 and ALA F 2 |
| Chain | Residue |
| F | ILE3 |
| F | LEU4 |
| F | HIS5 |
| F | LYS6 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 6 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"9338790","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"9600906","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1A52","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1ERE","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Phosphotyrosine; by Tyr-kinases","evidences":[{"source":"PubMed","id":"7539106","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | Lipidation: {"description":"S-palmitoyl cysteine","evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
