5WGD
Estrogen Receptor Alpha Ligand Binding Domain in Complex with Estradiol and SRC2-LP1
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 7 |
| Details | binding site for residue EST A 601 |
| Chain | Residue |
| A | MET343 |
| A | LEU346 |
| A | GLU353 |
| A | ARG394 |
| A | HIS524 |
| A | LEU525 |
| A | HOH788 |
| site_id | AC2 |
| Number of Residues | 7 |
| Details | binding site for residue EST B 601 |
| Chain | Residue |
| B | GLU353 |
| B | ARG394 |
| B | HIS524 |
| B | LEU525 |
| B | HOH791 |
| B | MET343 |
| B | LEU346 |
| site_id | AC3 |
| Number of Residues | 3 |
| Details | binding site for Ligand NH2 E 13 bound to SER E 12 |
| Chain | Residue |
| E | GLN10 |
| E | ASP11 |
| E | SER12 |
| site_id | AC4 |
| Number of Residues | 4 |
| Details | binding site for Ligand NH2 F 12 bound to SER F 11 |
| Chain | Residue |
| B | LYS362 |
| F | LEU8 |
| F | ASP10 |
| F | SER11 |
| site_id | AC5 |
| Number of Residues | 4 |
| Details | binding site for Di-peptide ACE F 1 and ALA F 2 |
| Chain | Residue |
| F | ILE3 |
| F | LEU4 |
| F | HIS5 |
| F | LYS6 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 130 |
| Details | DNA_BIND: Nuclear receptor => ECO:0000255|PROSITE-ProRule:PRU00407 |
| Chain | Residue | Details |
| A | ILE358-GLU423 | |
| B | ILE358-GLU423 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 88 |
| Details | ZN_FING: NR C4-type => ECO:0000255|PROSITE-ProRule:PRU00407 |
| Chain | Residue | Details |
| A | ILE358-LEU378 | |
| A | ARG394-VAL418 | |
| B | ILE358-LEU378 | |
| B | ARG394-VAL418 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphoserine; by CK2 => ECO:0000269|PubMed:7838153 |
| Chain | Residue | Details |
| A | ALA340 | |
| B | ALA340 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | MOD_RES: Asymmetric dimethylarginine; by PRMT1 => ECO:0000269|PubMed:18657504, ECO:0000269|PubMed:24498420 |
| Chain | Residue | Details |
| A | SER433 | |
| B | SER433 |
