5W9L

MERS S ectodomain trimer in complex with variable domain of neutralizing antibody G4

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, D, G, B, C...	Spike glycoprotein	polymer	1329	146326.0	6	UniProt (W5ZZF5) Pfam (PF16451) Pfam (PF09408) Pfam (PF19209) Pfam (PF01601) UniProt (by SIFTS) (K9N5Q8) In PDB	Middle East respiratory syndrome-related coronavirus	S protein
2	E, H	G4 VH	polymer	233	25312.4	2		Mus musculus
3	F, I	G4 VL	polymer	218	23867.4	2		Mus musculus

Sequence modifications

A, D, G, B, C, J: 1 - 1291 (UniProt: W5ZZF5)

PDB	External Database	Details
Phe 506	Leu 506	conflict
Ala 748	Arg 748	conflict
Gly 751	Arg 751	conflict
Pro 1060	Val 1060	engineered mutation
Pro 1061	Leu 1061	engineered mutation
Gly 1292	-	expression tag
Ser 1293	-	expression tag
Gly 1294	-	expression tag
Tyr 1295	-	expression tag
Ile 1296	-	expression tag
Pro 1297	-	expression tag
Glu 1298	-	expression tag
Ala 1299	-	expression tag
Pro 1300	-	expression tag
Arg 1301	-	expression tag
Asp 1302	-	expression tag
Gly 1303	-	expression tag
Gln 1304	-	expression tag
Ala 1305	-	expression tag
Tyr 1306	-	expression tag
Val 1307	-	expression tag
Arg 1308	-	expression tag
Lys 1309	-	expression tag
Asp 1310	-	expression tag
Gly 1311	-	expression tag
Glu 1312	-	expression tag
Trp 1313	-	expression tag
Val 1314	-	expression tag
Leu 1315	-	expression tag
Leu 1316	-	expression tag
Ser 1317	-	expression tag
Thr 1318	-	expression tag
Phe 1319	-	expression tag
Leu 1320	-	expression tag
Gly 1321	-	expression tag
Arg 1322	-	expression tag
Ser 1323	-	expression tag
Leu 1324	-	expression tag
Glu 1325	-	expression tag
Val 1326	-	expression tag
Leu 1327	-	expression tag
Phe 1328	-	expression tag
Gln 1329	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	10
	Total formula weight	976315.3
All*	Total formula weight	976315.3

*Water molecules are not included.