5W59
Crystal structure of a monomeric human FGF9 in complex with the ectodomain of human FGFR1c
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Fibroblast growth factor 9 | polymer | 175 | 19994.6 | 1 | UniProt (P31371) Pfam (PF00167) In PDB | Homo sapiens (Human) | FGF-9, Glia-activating factor, GAF, Heparin-binding growth factor 9, HBGF-9 |
2 | B | Fibroblast growth factor receptor 1 | polymer | 226 | 25436.1 | 1 | UniProt (P11362) Pfam (PF07679) In PDB | Homo sapiens (Human) | FGFR-1,Basic fibroblast growth factor receptor 1,bFGF-R-1,Fms-like tyrosine kinase 2,FLT-2,N-sam,Proto-oncogene c-Fgr |
3 | A | SULFATE ION | non-polymer | 96.1 | 3 | Chemie (SO4) | |||
4 | water | water | 18.0 | 90 | Chemie (HOH) |
Sequence modifications
A: 35 - 208 (UniProt: P31371)
B: 142 - 365 (UniProt: P11362)
PDB | External Database | Details |
---|---|---|
Met 34 | - | initiating methionine |
Ala 195 | Asp 195 | engineered mutation |
Ala 204 | Ile 204 | engineered mutation |
Ala 205 | Leu 205 | engineered mutation |
PDB | External Database | Details |
---|---|---|
Met 140 | - | expression tag |
Ala 141 | - | expression tag |
Gln 185 | Asn 185 | conflict |
Arg 252 | Pro 252 | conflict |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 2 |
Total formula weight | 45430.6 | |
Non-Polymers* | Number of molecules | 3 |
Total formula weight | 288.2 | |
All* | Total formula weight | 45718.8 |