5W59
Crystal structure of a monomeric human FGF9 in complex with the ectodomain of human FGFR1c
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Fibroblast growth factor 9 | polymer | 175 | 19994.6 | 1 | UniProt (P31371) Pfam (PF00167) | Homo sapiens (Human) | FGF-9, Glia-activating factor, GAF, Heparin-binding growth factor 9, HBGF-9 |
| 2 | B (B) | Fibroblast growth factor receptor 1 | polymer | 226 | 25436.1 | 1 | UniProt (P11362) Pfam (PF07679) | Homo sapiens (Human) | FGFR-1,Basic fibroblast growth factor receptor 1,bFGF-R-1,Fms-like tyrosine kinase 2,FLT-2,N-sam,Proto-oncogene c-Fgr |
| 3 | C, D, E (A) | SULFATE ION | non-polymer | 96.1 | 3 | Chemie (SO4) | |||
| 4 | F, G (A, B) | water | water | 18.0 | 90 | Chemie (HOH) |
Sequence modifications
A: 35 - 208 (UniProt: P31371)
B: 142 - 365 (UniProt: P11362)
| PDB | External Database | Details |
|---|---|---|
| Met 34 | - | initiating methionine |
| Ala 195 | Asp 195 | engineered mutation |
| Ala 204 | Ile 204 | engineered mutation |
| Ala 205 | Leu 205 | engineered mutation |
| PDB | External Database | Details |
|---|---|---|
| Met 140 | - | expression tag |
| Ala 141 | - | expression tag |
| Gln 185 | Asn 185 | conflict |
| Arg 252 | Pro 252 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 45430.6 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 288.2 | |
| All* | Total formula weight | 45718.8 |
