5W1Y
SETD8 in complex with a covalent inhibitor
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | N-lysine methyltransferase KMT5A | polymer | 166 | 18774.2 | 2 | UniProt (Q9NQR1) Pfam (PF00856) | Homo sapiens (Human) | H4-K20-HMTase KMT5A,Histone-lysine N-methyltransferase KMT5A,Lysine N-methyltransferase 5A,Lysine-specific methylase 5A,PR/SET domain-containing protein 07,PR/SET07,SET domain-containing protein 8 |
| 2 | C, S (A, B) | 2-(4-methylpiperazin-1-yl)-3-(phenylsulfanyl)naphthalene-1,4-dione | non-polymer | 364.5 | 2 | Chemie (9SV) | |||
| 3 | AA, BA, CA, D, DA... (B, A) | UNKNOWN ATOM OR ION | non-polymer | 36 | Chemie (UNX) | ||||
| 4 | OA, PA (A, B) | water | water | 18.0 | 208 | Chemie (HOH) |
Sequence modifications
A, B: 232 - 393 (UniProt: Q9NQR1)
| PDB | External Database | Details |
|---|---|---|
| Gly 228 | - | expression tag |
| Ala 229 | - | expression tag |
| Met 230 | - | expression tag |
| Gly 231 | - | expression tag |
| Ser 343 | Cys 343 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 37548.4 | |
| Non-Polymers* | Number of molecules | 38 |
| Total formula weight | 728.9 | |
| All* | Total formula weight | 38277.3 |
